炔烃双氢膦(酰)化反应的研究进展

doi:10.6023/cjoc202603007

综述与进展

炔烃双氢膦(酰)化反应的研究进展

成东婷^a,b, 朱能波^*,b, 鲍红丽^*,a,b,c,d

^a福建师范大学化学与材料学院福建福州 350007;
^b中国科学院福建物质结构研究所结构化学全国重点实验室福建福州 350002;
^c中国科学院大学福建学院福建福州 350002;
^d福州大学化学学院福建福州 350108

收稿日期:2026-03-05 修回日期:2026-04-18
基金资助:
国家自然科学基金(No. 22225107)和福建省自然科学基金(No. 2025J01249)资助项目

Recent Advances in the Double Hydrophosphination and Hydrophosphinylation of Alkynes

Dongting Cheng^a,b, Nengbo Zhu^*,b, Hongli Bao^*,a,b,c,d

^aCollege of Chemistry and Materials Science, Fujian Normal University, Fuzhou, Fujian Province, 350007;
^bFujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, State Key Laboratory of Structural Chemistry, Fuzhou, Fujian Province, 350002;
^cFujian College, University of Chinese Academy of Sciences, Fuzhou, Fujian Province, 350002;
^dCollege of Chemistry, Fuzhou University, Fuzhou, Fujian Province, 350108

Received:2026-03-05 Revised:2026-04-18
Contact: *E-mail: hlbao@fjirsm.ac.cn; zhunengbo@fjirsm.ac.cn
Supported by:
National Natural Science Foundation of China (No. 22225107) and the Natural Science Foundation of Fujian Province (No. 2025J01249)

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摘要/Abstract

双齿膦配体因其能够协同调控过渡金属中心的电子结构与空间构型, 在催化反应中发挥着重要作用. 近年来, 通过炔烃双氢膦(酰)化反应构建各类双膦配体的方法取得了长足发展, 该反应在选择性调控及底物适用范围等方面取得了显著进展. 本文从过渡金属催化与模板促进体系、非过渡金属体系以及自由基与光催化体系三个方面, 综述了不同类型炔烃双氢膦(酰)化反应的研究进展, 对比 1,1- 与 1,2- 二膦骨架构建中的区域与立体选择性规律, 分析催化剂失活等关键问题, 并对该领域发展前景进行展望.

关键词: 双氢膦化, P—C 键构筑, 双齿膦配体, 选择性调控, 催化剂失活

Bidentate phosphine ligands play an important role in catalysis because they can cooperatively regulate the electronic properties and steric environment of transition metal centers. In recent years, significant progress has been made in methods for constructing various diphosphine ligands through the double hydrophosphination (hydrophosphinylation) of alkynes. Considerable advances have been achieved in selectivity control and substrate scope. This review summarizes recent progress in alkyne double hydrophosphination (hydrophosphinylation) from three aspects: transition metal-catalyzed and template-promoted systems, non-transition-metal systems, and radical and photocatalytic systems. The regioselectivity and stereoselectivity in the formation of 1,1- and 1,2-diphosphine frameworks are analyzed. Key issues, such as catalyst deactivation, are also discussed. Finally, the future prospects of this field are outlined.

Key words: Double hydrophosphination, P—C bond formation, bidentate phosphine ligand, selectivity control, catalyst deactivation

引用此文

成东婷, 朱能波, 鲍红丽. 炔烃双氢膦(酰)化反应的研究进展[J]. 有机化学, doi: 10.6023/cjoc202603007.

Dongting Cheng, Nengbo Zhu, Hongli Bao. Recent Advances in the Double Hydrophosphination and Hydrophosphinylation of Alkynes[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202603007.

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