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2012 , Vol. 32 >Issue 06: 1141 - 1145

DOI: https://doi.org/10.6023/cjoc1109222

研究简报

2-氨基-4,5-二取代烃嘧啶类衍生物的新合成方法

  • 邓兰青 ,
  • 徐中海 ,
  • 尚云峰 ,
  • 戴文静 ,
  • 胡辉敏 ,
  • 邓穗平 ,
  • 欧阳健明
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  • a 岳阳职业技术学院 岳阳市中草药综合利用重点实验室 岳阳 414000;
    b 暨南大学生物矿化与结石病防治研究所 广州 510632

收稿日期: 2011-09-22

  修回日期: 2011-12-20

  网络出版日期: 2012-02-14

基金资助

国家自然科学基金(No. 30672103)和湖南省教育厅(No. 10C0336)资助项目.

收起

A New Synthesis of 2-Amino-4,5-substituted Pyrimidine Derivatives

  • Deng Lanqing ,
  • Xu Zhonghai ,
  • Shang Yunfeng ,
  • Dai Wenjing ,
  • Hu Huimin ,
  • Deng Suiping ,
  • Ouyang Jianming
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  • a Key Laboratory of Yueyang Chinese Herbal Utilization, Yueyang Vocational Technical College, Yueyang 414000;
    b Institute of Biomineralization and Lithiasis Research, Jinan University, Guangzhou 510632

Received date: 2011-09-22

  Revised date: 2011-12-20

  Online published: 2012-02-14

Supported by

Project supported by the National Natural Science Foundation of China (No. 30672103) and the Fundation of Hunan Educational Committee (No. 10C0336).

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摘要

研究了2-氨基-4,5-二烃基取代嘧啶类衍生物的一个新的简易合成方法, 该方法以简单且廉价的4 个芳香醛和3个脂肪醛为原料, 经过四步反应得到12 个2-氨基-4,5-二烃基取代嘧啶类化合物, 总收率在40%～70%, 经氢核磁共振(1H NMR)、碳核磁共振(13C NMR)和高效液质联用(LC-MS)对其目标产物进行表征.

关键词： 2-氨基嘧啶; 芳香醛; 脂肪醛; 合成性

本文引用格式

邓兰青 , 徐中海 , 尚云峰 , 戴文静 , 胡辉敏 , 邓穗平 , 欧阳健明 . 2-氨基-4,5-二取代烃嘧啶类衍生物的新合成方法[J]. 有机化学, 2012 , 32(06) : 1141 -1145 . DOI: 10.6023/cjoc1109222

Abstract

In this paper, a novel synthetic method for 2-amino-4,5-substituted pyrimidine derivatives was reported, which began from cheap and simple four aromatic aldehydes and three aliphatic aldehydes. 12 compounds of 2-amino-4,5-substituted pyrimidine derivatives were synthesized by four steps with yields of 40%～70%. The structures of terminational compounds were determined by 1H NMR, 13C NMR and LC-MS techniques.

Key words： 2-amino-pyrimidine; aromatic aldehyde; aliphatic aldehyde; synthesis

参考文献

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