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2012 , Vol. 32 >Issue 05: 907 - 914

DOI: https://doi.org/10.6023/cjoc1108171

研究论文

无溶剂无催化剂条件下二硫代氨基甲酸酯衍生物的合成研究

  • 郭圣荣 ,
  • 袁艳琴 ,
  • 张春牛
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  • 丽水学院化学化工系 丽水 323000

收稿日期: 2011-08-17

  修回日期: 2011-12-27

  网络出版日期: 2012-01-10

基金资助

浙江省自然科学基金(No. Y407240)和丽水学院重点科研(No. KZ201103)资助项目.

收起

Highly Efficient Catalyst-Free One-Pot Synthesis of Dithiocarbamates under Solvent-Free Conditions

  • Guo Shengrong ,
  • Yuan Yanqin ,
  • Zhang Chunniu
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  • Department of Chemistry, Lishui University, Lishui 323000

Received date: 2011-08-17

  Revised date: 2011-12-27

  Online published: 2012-01-10

Supported by

Project supported by the Natural Science Foundation of Zhejiang Province (No. Y407240) and the Key Science Foundation of Lishui University (No. KZ201103).

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摘要

主要研究了二硫代氨基甲酸酯衍生物的合成, 将脂肪胺、CS2 与α,β-不饱和羰基化合物或卤代烃在无溶剂无催化剂室温条件下, “一锅法”进行了Michael-type 的加成反应, 合成了二硫代氨基甲酸酯衍生物. 该方法产率高, 操作简单, 是一种原子经济的合成方法, 并可大规模地用于制药及农药方面.

关键词： 二硫代氨基甲酸酯; 无溶剂; 二硫化碳; α,β-不饱和羰基化合物

本文引用格式

郭圣荣 , 袁艳琴 , 张春牛 . 无溶剂无催化剂条件下二硫代氨基甲酸酯衍生物的合成研究[J]. 有机化学, 2012 , 32(05) : 907 -914 . DOI: 10.6023/cjoc1108171

Abstract

A highly efficient and simple synthesis of dithiocarbamates is reported in the one-pot reaction of amines, CS2, and alkyl halides without using a catalyst under solvent-free conditions. The mild reaction conditions, high yields, and broad scope of the reaction illustrate the good synthetic utility of this method. The reaction is a highly atom-economic process for production of dithiocarbamates and can be successfully used in large amount for the pharmaceutical or agrochemical industries.

Key words： dithiocarbamates; solvent-free; carbon disulfide; α,β-unsaturated compounds

参考文献

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