在乙醇钠的催化下, 4-[(三苯基膦叶立德)氨基]-2,3-二氢-3-苯基-2-硫代噻唑-5-羧酸乙酯(膦亚胺1)与芳香基二异氰酸酯和亲核试剂的双氮杂Wittig反应制得苯桥连的双[噻唑并[4,5-d]嘧啶-7(6H)-酮]衍生物, 产率为56%～92%. 产物结构经IR, 1H NMR, MS和元素分析确证.
方正东
,
袁意
,
叶华林
. 苯桥连的双[噻唑并[4,5-d]嘧啶-7(6H)-酮]衍生物的合成[J]. 有机化学, 2012
, 32(12)
: 2354
-2357
.
DOI: 10.6023/cjoc201207037
Bis-aza-Wittig reactions of ethyl 4-[(triphenylphosphanylidene)amino]-2,3-dihydro-3-phenyl-2-thioxothiazole-5-carboxylate (iminophosphorane 1) with aromatic diisocyanate and nucleophilic reagents produced novel benzene-bridged bis(thiazolo[4,5-d]pyrimidin-7(6H)-one) derivatives in the presence of EtONa in 56%～92% yields. The structures of compounds were confirmed by 1H NMR, IR, MS and elemental analysis.
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