有机化学 ›› 2012, Vol. 32 ›› Issue (12): 2354-2357.DOI: 10.6023/cjoc201207037 上一篇    下一篇

研究简报

苯桥连的双[噻唑并[4,5-d]嘧啶-7(6H)-酮]衍生物的合成

方正东, 袁意, 叶华林   

  1. 湖北师范学院化学与环境工程学院 黄石 435002
  • 收稿日期:2012-07-25 修回日期:2012-08-21 发布日期:2012-08-27
  • 通讯作者: 方正东 E-mail:zdfangluo@sina.com
  • 基金资助:
    湖北省自然科学基金(No. 2010CDA061)资助项目.

Synthesis of Benzene-Bridged Bis(thiazolo[4,5-d]pyrimidin-7(6H)-one) Derivatives

Fang Zhengdong, Yuan Yi, Ye Hualing   

  1. College of Chemistry and Environmental Engineering, Hubei Normal University, Huangshi 435002
  • Received:2012-07-25 Revised:2012-08-21 Published:2012-08-27
  • Supported by:
    Project supported by the Natural Science Foundation of Hubei Province (No. 2010CDA061).

在乙醇钠的催化下, 4-[(三苯基膦叶立德)氨基]-2,3-二氢-3-苯基-2-硫代噻唑-5-羧酸乙酯(膦亚胺1)与芳香基二异氰酸酯和亲核试剂的双氮杂Wittig反应制得苯桥连的双[噻唑并[4,5-d]嘧啶-7(6H)-酮]衍生物, 产率为56%~92%. 产物结构经IR, 1H NMR, MS和元素分析确证.

关键词: 苯桥连, 噻唑并[4,5-d]嘧啶-7(6H)-酮, 多组分反应, 膦亚胺

Bis-aza-Wittig reactions of ethyl 4-[(triphenylphosphanylidene)amino]-2,3-dihydro-3-phenyl-2-thioxothiazole-5-carboxylate (iminophosphorane 1) with aromatic diisocyanate and nucleophilic reagents produced novel benzene-bridged bis(thiazolo[4,5-d]pyrimidin-7(6H)-one) derivatives in the presence of EtONa in 56%~92% yields. The structures of compounds were confirmed by 1H NMR, IR, MS and elemental analysis.

Key words: benzene-bridged, thiazolo[4,5-d]pyrimidin-7(6H)-one, multicomponent reaction, iminophosphorane