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2013 , Vol. 33 >Issue 02: 348 - 352

DOI: https://doi.org/10.6023/cjoc201209025

研究论文

三组分反应合成1,4-[6,6'-(3-三氟甲基吡唑并[3,4-d]嘧啶)]哌嗪衍生物

  • 方正东 ,
  • 方迪 ,
  • 陈全
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  • 湖北师范学院化学与环境工程学院 黄石 435002

收稿日期: 2012-09-18

  修回日期: 2012-10-13

  网络出版日期: 2012-10-25

基金资助

湖北省自然科学基金(No. 2010CDA061)资助项目.

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Three-Component Synthesis of 1,4-[6,6'-(3-Trifluoromethyl-pyrazolo[3,4-d]pyrimidinyl)]piperazines

  • Fang Zhengdong ,
  • Fang Di ,
  • Chen Quan
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  • College of Chemistry and Environmental Engineering, Hubei Normal University, Huangshi 435002

Received date: 2012-09-18

  Revised date: 2012-10-13

  Online published: 2012-10-25

Supported by

Project supported by the Natural Science Foundation of Hubei Province (No. 2010CDA061).

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摘要

在乙醇钠的催化下, 1-苯基-3-三氟甲基-5-(三苯基氨基膦叶立德)-4-羧酸乙酯(膦亚胺2)、芳基异氰酸酯与无水哌嗪或其取代物的三组分反应制得1,4-[6,6'-(3-三氟甲基吡唑并[3,4-d]嘧啶)]哌嗪衍生物, 产率为55%～87%. 产物结构经1H NMR, IR, MS表征和元素分析确证.

关键词： 哌嗪; 吡唑并[3,4-d]嘧啶; 多组分反应; 合成

本文引用格式

方正东 , 方迪 , 陈全 . 三组分反应合成1,4-[6,6'-(3-三氟甲基吡唑并[3,4-d]嘧啶)]哌嗪衍生物[J]. 有机化学, 2013 , 33(02) : 348 -352 . DOI: 10.6023/cjoc201209025

Abstract

Three-component reactions of ethyl 1-phenyl-3-trifloromethyl-5-[(triphenylphosphanylidene)amino]-4-carboxylate (iminophosphorane 2) with aromatic isocyanate and piperazine derivatives produced novel 1,4-[6,6'-(3-trifluoromethyl-pyrazolo[3,4-d]pyrimidinyl)]piperazines in the presence of EtONa in 55%～87% yields. The structures of synthetic compounds were confirmed by 1H NMR, IR, MS techniques and elemental analysis.

Key words： piperazine; pyrazolo[3,4-d]pyrimidine; multi-component reaction; synthesis

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