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2013 , Vol. 33 >Issue 02: 365 - 369

DOI: https://doi.org/10.6023/cjoc201210003

研究简报

小远志多糖一级结构的初步研究

  • 陈良凤 ,
  • 周俊 ,
  • 宛瑜 ,
  • 吴翚
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  • a 江苏师范大学化学化工学院 徐州 221116;
    b 江苏恩华药业股份有限公司 徐州 221007;
    c 江苏省药物植物生物技术重点实验室 徐州 221116

收稿日期: 2012-10-05

  修回日期: 2012-11-13

  网络出版日期: 2012-11-23

基金资助

江苏省高校自然科学(Nos. 10KJA430050, 11KJB150017)和江苏省普通高校研究生科研创新计划(No. CXZZ12_0979)资助项目.

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Preliminary Study on the Primary Structure of Polygala sibirica L. var megalopha Fr. Polysaccrides

  • Chen Liangfeng ,
  • Zhou Jun ,
  • Wan Yu ,
  • Wu Hui
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  • a School of Chemistry and Chemical Engineering, Jiangsu Normal University, Xuzhou 221116;
    b Jiangsu Nhwa Pharmaceutical Group, Xuzhou 221007;
    c Jiangsu Key Laboratory of Biotechnology on Medical Plant, Xuzhou 221116

Received date: 2012-10-05

  Revised date: 2012-11-13

  Online published: 2012-11-23

Supported by

Project supported by the Key Basic Research Project in Jiangsu University (Nos. 10KJA430050, 11KJB150017), and the Graduate Innovation Project in Jiangsu Province (No. CXZZ12_0979).

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摘要

从药用植物小远志中提取、精制得多糖PP-1, PP-2, 采用纸层析、薄层层析和气相色谱等方法确定了多糖中的单糖组成. 通过高碘酸氧化、Smith降解和甲基化分析等方法确定了相邻单糖基连接方式, 初步推测了两个小远志多糖可能的一级结构, 为进一步合成和研究其生物活性提供了数据支持.

关键词： 小远志多糖; 组成; 一级结构

本文引用格式

陈良凤 , 周俊 , 宛瑜 , 吴翚 . 小远志多糖一级结构的初步研究[J]. 有机化学, 2013 , 33(02) : 365 -369 . DOI: 10.6023/cjoc201210003

Abstract

Two polysaccharides PP-1 and PP-2 were isolated and purified from Polygala sibirica L. var megalopha Fr. Their constituents were analyzed by paper chromatography, thin-layer chromatography (TLC) and gas chromatography (GC), and the link typies between monosaccharides were determined via periodate-oxidation, Smith degradation and methylation etc. Then their possible primary structure was inferred for the further investigation of their synthesis and bioactivity.

Key words： Polygala sibirica L. var megalopha Fr. polysaccharide; composition; primary structure

参考文献

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[5] Wu, H.; Zhou, J.; Wan, Y.; Shi, D.-Q. J. Xuzhou Normal Univ. 2004, 22, 52 (in Chinese). (吴翚, 周俊, 宛瑜, 史达清, 徐州师范大学学报, 2004, 22, 52.)

[6] Yu, H.-Z.; Wu, H.; Du, B.-X. J. Xuzhou Normal Univ. 2005, 23, 71 (in Chinese). (郁惠珍, 吴翚, 杜百祥, 徐州师范大学学报, 2005, 23, 71.)

[7] Zhang, W.-J. Biochemical Research Techniques of Complex polysaccharides, Zhejiang University Press, Hangzhou, 1994, pp. 245～252 (in Chinese). (张惟杰, 复合多糖生化研究技术, 浙江大学出版社, 杭州, 1994, pp. 245～252.)

[8] Biemann, C. J.; Macginnis, G. D. Analysis of Carbohydrates by Glc and MS, CRC Press, Florida, 1989, pp. 157～216.
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