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2013 , Vol. 33 >Issue 04: 860 - 865

DOI: https://doi.org/10.6023/cjoc201301012

研究论文

铜催化胺与1,3-二羰基化合物的缩合反应合成烯胺酮化合物

  • 瞿益萍 ,
  • 王龙翔 ,
  • 周晓玉 ,
  • 冯秀娟 ,
  • 包明
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  • 大连理工大学精细化工国家重点实验室 大连 116023

收稿日期: 2013-01-05

  修回日期: 2013-01-25

  网络出版日期: 2013-02-01

基金资助

国家自然科学基金(No. 21073025)资助项目.

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Copper-Catalyzed Condensation Reaction of Amines with 1,3-Dicarbonyl Compounds to Produce Enaminones

  • Qu Yiping ,
  • Wang Longxiang ,
  • Zhou Xiaoyu ,
  • Feng Xiujuan ,
  • Bao Ming
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  • State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116023

Received date: 2013-01-05

  Revised date: 2013-01-25

  Online published: 2013-02-01

Supported by

Project supported by the National Natural Science Foundation of China (No. 21073025).

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摘要

报道了铜催化胺与1,3-二羰基化合物的缩合反应. 在CuCl催化剂的存在下, 胺与1,3-二羰基化合物的缩合反应, 可在四氢呋喃溶剂中、室温条件下顺利进行, 生成烯胺酮化合物, 收率为75%～98%. 合成了16种烯胺酮化合物3a～3p, 其中, 3p为未知化合物.

本文引用格式

瞿益萍 , 王龙翔 , 周晓玉 , 冯秀娟 , 包明 . 铜催化胺与1,3-二羰基化合物的缩合反应合成烯胺酮化合物[J]. 有机化学, 2013 , 33(04) : 860 -865 . DOI: 10.6023/cjoc201301012

Abstract

Copper-catalyzed condensation reaction of amines with 1,3-dicarbonyl compounds is described. The condensation reaction of amines with 1,3-dicarbonyl compounds proceeded smoothly in the presence of copper chloride (CuCl) catalyst at room temperature in tetrahydrofuran (THF) to produce enaminones in range of 75%～98% yields. Sixteen kinds of enaminones 3a～3p were prepared, and the 3p is an unknown product.

Key words： copper catalysis; amine; 1,3-dicarbonyl compound; enaminone; synthesis

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