1-(香豆素-3-酰基)愈创兰烃薁的合成及其抗菌活性
收稿日期: 2013-01-17
修回日期: 2013-02-25
网络出版日期: 2013-03-07
基金资助
辽宁省科技厅(No. 2011220022)和黑龙江中医药大学优秀创新人才支持计划资助项目.
Synthesis and Antibacterial Activity of 1-(Coumarin-3-carbonyl)guaiazulene Derivatives
Received date: 2013-01-17
Revised date: 2013-02-25
Online published: 2013-03-07
Supported by
Project supported by the Science and Technology Department of Liaoning Province (No. 2011220022), and the Innovation Talent Program of Heilongjiang University of Chinese Medicine.
王道林 , 董哲 , 徐姣 , 李帝 . 1-(香豆素-3-酰基)愈创兰烃薁的合成及其抗菌活性[J]. 有机化学, 2013 , 33(07) : 1559 -1563 . DOI: 10.6023/cjoc201301025
An efficient and easy method for the synthesis of 1-(coumarin-3-carbonyl)guaiazulene derivatives by the condensation of 1-cyanoacetylguaiazulene and 2-hydroxyaldehydes in the presence of ammonium acetate has been described. The structures of all target compounds have been confirmed by NMR, IR, MS spectra and elemental analysis, and the bioassay result indicated that some of the title compounds had relatively antibacterial activity.
Key words： azulene; guaiazulene; coumarin; synthesis; antibacterial activity
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