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2013 , Vol. 33 >Issue 08: 1728 - 1733

DOI: https://doi.org/10.6023/cjoc201302019

研究论文

离子液体中吡喃并[3,2-c]吡啶衍生物的绿色合成

  • 张梅梅 ,
  • 周玉静 ,
  • 李玉玲 ,
  • 刘蕴 ,
  • 王香善
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  • a 江苏师范大学江苏省药用植物生物技术重点实验室 徐州 221116;
    b 江苏师范大学化学化工学院 徐州 221116

收稿日期: 2013-02-26

  修回日期: 2013-04-09

  网络出版日期: 2013-04-17

基金资助

国家自然科学基金(Nos. 20802061, 21104064);青蓝工程基金(Nos. 10QLD008, GSFM2011003);江苏省高校产业化基金(No. JHB2012-31)资助项目.

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Green Synthesis of Pyrano[3,2-c]pyridine Derivatives in Ionic Liquids

  • Zhang Meimei ,
  • Zhou Yujing ,
  • Li Yuling ,
  • Liu Yun ,
  • Wang Xiangshan
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  • a Key Laboratory of Biotechnology on Medical Plant of Jiangsu Province, Jiangsu Normal University, Xuzhou 221116;
    b School of Chemistry and Chemical Engineering, Jiangsu Normal University, Xuzhou 221116

Received date: 2013-02-26

  Revised date: 2013-04-09

  Online published: 2013-04-17

Supported by

Project supported by the National Natural Science Foundation of China (Nos. 20802061, 21104064), the Qing Lan Project (Nos. 10QLD008, GSFM2011003) and the College Industrialization Project (No. JHB2012-31) of Jiangsu Province.

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摘要

介绍了一种以离子液体为介质合成2-氨基-4-芳基-7,8-二氢化-5-氧代-4H-吡喃并[3,2-c]吡啶-6-羧酸叔丁酯衍生物的方法. 该方法包含芳醛、丙二腈或氰乙酸酯和2,4-二氧代吡啶-1-羧酸叔丁酯的三组分反应, 具有产率高和环境友好的优点.

关键词： 吡喃并吡啶; 丙二腈; 离子液体; 合成

本文引用格式

张梅梅 , 周玉静 , 李玉玲 , 刘蕴 , 王香善 . 离子液体中吡喃并[3,2-c]吡啶衍生物的绿色合成[J]. 有机化学, 2013 , 33(08) : 1728 -1733 . DOI: 10.6023/cjoc201302019

Abstract

A green and facile method for the synthesis of tert-butyl 2-amino-4-aryl-7,8-dihydro-5-oxo-4H-pyrano-[3,2-c]pyridine-6(5H)-carboxylate derivatives, is described in good to high yields using ionic liquids as green media. The method involves a three-component reaction of aromatic aldehyde, malononitrile or cyanacetate and tert-butyl 2,4-dioxopiperidine-1-carboxylate.

Key words： pyranopyridine; malononitrile; ionic liquid; synthesis

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(王树良, 杨科, 王香善, 有机化学, 2011, 31, 1235.)
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