有机化学 ›› 2013, Vol. 33 ›› Issue (08): 1728-1733.DOI: 10.6023/cjoc201302019 上一篇    下一篇

研究论文

离子液体中吡喃并[3,2-c]吡啶衍生物的绿色合成

张梅梅a, 周玉静b, 李玉玲b, 刘蕴b, 王香善a,b   

  1. a 江苏师范大学江苏省药用植物生物技术重点实验室 徐州 221116;
    b 江苏师范大学化学化工学院 徐州 221116
  • 收稿日期:2013-02-26 修回日期:2013-04-09 发布日期:2013-04-17
  • 通讯作者: 王香善 E-mail:xswang1974@yahoo.com
  • 基金资助:

    国家自然科学基金(Nos. 20802061, 21104064);青蓝工程基金(Nos. 10QLD008, GSFM2011003);江苏省高校产业化基金(No. JHB2012-31)资助项目.

Green Synthesis of Pyrano[3,2-c]pyridine Derivatives in Ionic Liquids

Zhang Meimeia, Zhou Yujingb, Li Yulingb, Liu Yunb, Wang Xiangshana,b   

  1. a Key Laboratory of Biotechnology on Medical Plant of Jiangsu Province, Jiangsu Normal University, Xuzhou 221116;
    b School of Chemistry and Chemical Engineering, Jiangsu Normal University, Xuzhou 221116
  • Received:2013-02-26 Revised:2013-04-09 Published:2013-04-17
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 20802061, 21104064), the Qing Lan Project (Nos. 10QLD008, GSFM2011003) and the College Industrialization Project (No. JHB2012-31) of Jiangsu Province.

介绍了一种以离子液体为介质合成2-氨基-4-芳基-7,8-二氢化-5-氧代-4H-吡喃并[3,2-c]吡啶-6-羧酸叔丁酯衍生物的方法. 该方法包含芳醛、丙二腈或氰乙酸酯和2,4-二氧代吡啶-1-羧酸叔丁酯的三组分反应, 具有产率高和环境友好的优点.

关键词: 吡喃并吡啶, 丙二腈, 离子液体, 合成

A green and facile method for the synthesis of tert-butyl 2-amino-4-aryl-7,8-dihydro-5-oxo-4H-pyrano-[3,2-c]pyridine-6(5H)-carboxylate derivatives, is described in good to high yields using ionic liquids as green media. The method involves a three-component reaction of aromatic aldehyde, malononitrile or cyanacetate and tert-butyl 2,4-dioxopiperidine-1-carboxylate.

Key words: pyranopyridine, malononitrile, ionic liquid, synthesis