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2013 , Vol. 33 >Issue 06: 1284 - 1290

DOI: https://doi.org/10.6023/cjoc201303041

研究论文

棠梨枝叶的化学成分研究

  • 赵冕 ,
  • 蔡乐 ,
  • 何健民 ,
  • 尹田鹏 ,
  • 隋迎春 ,
  • 罗梦婷 ,
  • 丁中涛
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  • a 教育部自然资源药物化学重点实验室 云南大学化学科学与工程学院 昆明 650091;
    b 保山学院资源环境学院 保山 678000

收稿日期: 2013-03-26

  修回日期: 2013-04-25

  网络出版日期: 2013-05-06

基金资助

国家自然科学基金(No.21002084)和云南省自然科学基金(No.2010CD017)资助项目.

收起

Chemical Constituents from the Branches and Leaves of Pyrus pashia Buch.-Ham.ex D.Don

  • Zhao Mian ,
  • Cai Le ,
  • He Jianmin ,
  • Yin Tianpeng ,
  • Sui Yingchun ,
  • Luo Mengting ,
  • Ding Zhongtao
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  • a Key Laboratory of Medicinal Chemistry for Nature Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091;
    b College of Resource and Environment, Baoshan University, Baoshan 678000

Received date: 2013-03-26

  Revised date: 2013-04-25

  Online published: 2013-05-06

Supported by

Project supported by the National Natural Science Foundation of China (No.21002084), and the Natural Science Foundation of China of Yunnan Province (No.2010CD017).

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摘要

从棠梨枝叶(Pyrus pashia Buch.-Ham.ex D.Don)的甲醇提取物中分离得到了17个化合物, 采用高分辨质谱、一维和二维核磁共振等现代波谱技术, 鉴定上述化合物的结构分别为: pashinin A (1), 天麻苷-7-O-顺式咖啡酸酯(2), 天麻苷-7-O-反式咖啡酸酯(3), 山奈酚-3-O-β-D-(6"-O-对香豆酸酯)吡喃葡萄糖苷(4), 山奈酚-3-O-β-D-(6"-O-顺式对香豆酰)吡喃葡萄糖苷(5), 天麻苷-7-O-对羟基苯甲酸酯(6), 熊果苷(7), robustaside B (8), 委陵菜酸(9), 蔷薇酸(10), 槲皮素3-O-β-D-吡喃葡萄糖苷(11), 2R,3R-二氢槲皮素(12), 木犀草素-4'-O-β-D-吡喃葡萄糖苷(13), 芹黄素-4'-O-β-D-吡喃葡萄糖苷(14), 5,7,4'-三羟基异黄酮-7-O-β-D-吡喃葡萄糖苷(15), 染料木素(16), 咖啡酸(17), 其中化合物1和2为新化合物, 化合物3为新的天然产物.除化合物17外, 其余化合物均首次从该植物中分离得到.化合物1～3的抗肿瘤细胞活性实验表明其没有体外肿瘤细胞生长抑制活性(IC50 >40 μmol·L-1); 抗HIV病毒(HIV-1IIIB)实验显示: 化合物1有极弱的抗HIV-1的活性, 化合物4有弱的抗HIV-1的活性.

关键词： 棠梨; 枝叶; pashinin A; 天麻苷-7-O-顺式咖啡酸酯; 抗HIV-1活性

本文引用格式

赵冕 , 蔡乐 , 何健民 , 尹田鹏 , 隋迎春 , 罗梦婷 , 丁中涛 . 棠梨枝叶的化学成分研究[J]. 有机化学, 2013 , 33(06) : 1284 -1290 . DOI: 10.6023/cjoc201303041

Abstract

Seventeen compounds were isolated from the branches and leaves of Pyrus pashia Buch.-Ham.ex D.Don.On the basis of spectroscopic methods (HR-ESIMS, 1D- and 2D-NMR), their structures were identified as pashinin A (1), gastrodin-7-O-cis-caffeoyl ester (2), gastrodin-7-O-trans-caffeoyl ester (3), kaempferol-3-β-D-(6-O-trans-p-coumaroyl)glu- copyranoside (4), kaempferol-3-β-D-(6-O-cis-p-coumaroyl)glucopyranoside (5), gastrodin-7-O-p-hydroxybenzoyl ester (6), arbutin (7), robustaside B (8), tormentic acid (9), euscaphic acid (10), quercetin-3-O-β-D-glucopyranoside (11), 2R,3R-dihydyoquercetin (12), luteolin-4'-O-β-D-glucopyranoside (13), apigenin-4'-O-β-D-glucopyranoside (14), 5,7,4'-trihy- droxyisoflavone-7-O-β-D-glucopyranoside (15), genistein (16), caffeic acid (17).Among them, 1 and 2 were new compounds, 3 was a new natural product, 4～16 were isolated from this plant for the first time.Compounds 1～3 showed no cytotoxic effects on tumor cell (IC50 >40 μmol·L-1).1 and 4 exhibited weak anti-HIV-1 activities.

Key words： Pyrus pashia; branches and leaves; pashinin A; gastrodin-7-O-cis-caffeoyl ester; anti-HIV-1 activities

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