TiCl4催化一锅法三组分合成β-氨基酮化合物
收稿日期: 2013-06-06
修回日期: 2013-07-10
网络出版日期: 2013-07-26
基金资助
北京理工大学基础研究基金资助项目
One-Pot Three Components Synthesis of β-Amido Ketones
Received date: 2013-06-06
Revised date: 2013-07-10
Online published: 2013-07-26
Supported by
Project supported by the Foundation of Beijing Institute of Technology.
杨德利 , 李加荣 , 孙克宁 , 路红燕 , 刘明星 , 史大昕 . TiCl4催化一锅法三组分合成β-氨基酮化合物[J]. 有机化学, 2013 , 33(11) : 2341 -2348 . DOI: 10.6023/cjoc201306007
A series of β-amido-ketones were synthesized by one-pot three components condensation of various aldehydes, ketones and nitriles in the presence of TiCl4 with the assistance of acyl chloride at room temperature. The effects of amount of catalyst, reaction temperature and reaction time on the products yields were investigated. This methodology offers several ad-vantages, such as mild reaction condition, operational simplicity, suitable for wide range of substrates, and excellent yields.
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