新型5,6-2H-Lamellarin η及其类似物全合成研究
收稿日期: 2013-07-16
修回日期: 2013-09-18
网络出版日期: 2013-10-10
基金资助
国家自然科学基金（No.21271036）、大连市优秀青年科技人才基金（No.2009J22DW038）资助项目.
Synthesis of Novel 5,6-2H-Lamellarin η and Analogues
Received date: 2013-07-16
Revised date: 2013-09-18
Online published: 2013-10-10
Supported by
Project supported by the National Natural Science Foundation of China (No. 21271036) and the Outstanding Young Talent Fund from the Dalian Science and Technology Bureau (No. 2009J22DW038).
以2，4-二异丙氧基-α-溴代苯乙酮类化合物1a， 1b和异喹啉类化合物1c为原料，通过“Knorr缩合-酯化-关环”的方法，成功地合成目标化合物5，6-2H-Lamellarin η（5a）及其类似物5b，同时得到了两种新型的开链Lamellarin（化合物Ⅰ、Ⅱ）. 本研究共合成10种化合物，其中6种为新化合物，其结构通过1H NMR，13C NMR，MS，IR，HRMS谱图手段进行了表征.
关键词： 5,6-2H-Lamellarin η; 合成; Knorr缩合
王爱玲 , 郑学良 , 赵壮志 , 李长平 , 陶波 , 郑学仿 . 新型5,6-2H-Lamellarin η及其类似物全合成研究[J]. 有机化学, 2014 , 34(2) : 429 -433 . DOI: 10.6023/cjoc201307023
According to the reaction of "Knorr condensation-esterification-cyclization", the target compounds, 6-2H- lamellarin η (5a) and analogues 5b were synthesized successfully from 2,4-diisopropoxy-α-bromo-acetophenone compounds 1a, 1b and the isoquinoline compound 1c. Two kinds of novel open-chain lamellarins (compounds Ⅰ, Ⅱ) were accompanied to obtain during the synthesis of 5a. In this paper, ten compounds had been got including six new compounds, which are identified by 1H NMR, 13C NMR, MS, IR, HRMS techniques.
Key words： 5,6-2H-lamellarin η; synthesis; Knorr condensation
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