三组分合成噁唑并[3,4-b]喹啉衍生物
收稿日期: 2013-09-08
修回日期: 2013-10-14
网络出版日期: 2013-10-28
基金资助
国家自然科学青年基金(No. 21102124)和江苏省“青蓝”工程(No. 12QLG006)资助项目.
Three-Component Synthesis of Oxazolo[3,4-b]quinoline Derivatives
Received date: 2013-09-08
Revised date: 2013-10-14
Online published: 2013-10-28
Supported by
Project supported by the National Natural Science Foundation of China (No. 21102124) and the Qing Lan Project of Jiangsu Province (No. 12QLG006).
1，2-吖啶二酮衍生物、醛和醋酸铵在N，N-二甲基甲酰胺溶剂中经微波辐射，一步区域选择性地合成了噁唑并[3，4-b]喹啉衍生物. 该方法具有反应时间短(15～18 min)，选择性高，操作简单和环境友好等优点. 产物的结构经红外光谱、核磁共振谱、质谱以及化合物4a的晶体经X射线衍射分析予以确证.
关键词： 微波辐射; 噁唑并[3,4-b]喹啉衍生物; 五环稠杂环; 三组分反应
佟光进 , 范威 , 姜波 . 三组分合成噁唑并[3,4-b]喹啉衍生物[J]. 有机化学, 2013 , 33(12) : 2578 -2582 . DOI: 10.6023/cjoc201309014
A series of oxazolo[3,4-b]quinoline derivatives were regioselectively synthesized by the three component reaction of acridin-1,2-dione derivatives with aldehydes and ammonium acetate in N,N-dimethylformamide (DMF) under microwave irradiation. This method has the advantages of short reaction times (15～18 min), excellent selectivity, and simple operation as well as environmental friendly. The structures of the products were identified by IR, NMR, HRMS, and the crystal of compound 4a was confirmed by X-ray diffraction.
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