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2014 , Vol. 34 >Issue 4: 817 - 820

DOI: https://doi.org/10.6023/cjoc201311024

研究简报

二醋酸碘苯促进的芳酮类化合物羰基邻位乙酰化反应研究

  • 谭丽泉 ,
  • 刘卫兵 ,
  • 黄敏 ,
  • 余梅
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  • 广东石油化工学院化学与生命科学学院 茂名 525000

收稿日期: 2013-11-13

  修回日期: 2013-12-14

  网络出版日期: 2014-01-02

基金资助

广东省自然科学基金（No. S2012040007868）资助项目

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α-Acetoxylation of Aromatic Ketones Mediated by Iodobenzene Diacetate

  • Tan Liquan ,
  • Liu Weibing ,
  • Huang Min ,
  • Yu Mei
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  • School of Chemistry and Life Science, Guangdong University of Petrochemical Technology, Maoming 525000

Received date: 2013-11-13

  Revised date: 2013-12-14

  Online published: 2014-01-02

Supported by

Project supported by the Natural Science Foundation of Guangdong Provine (No. S2012040007868).

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摘要

以苯乙酮类化合物为原料，氧化锌（ZnO）为催化剂，二醋酸碘苯为氧化剂，通过对羰基邻位饱和sp3-C—H键的氧化与乙酰化，成功的构建出了α-乙酸基苯乙酮类衍生物，其结构经1H NMR和13C NMR得到了确认，并提出了可能的反应机理.

关键词： 二醋酸碘苯; 乙酰苯酮; 饱和sp3-C—H键氧化; 乙酰化

本文引用格式

谭丽泉 , 刘卫兵 , 黄敏 , 余梅 . 二醋酸碘苯促进的芳酮类化合物羰基邻位乙酰化反应研究[J]. 有机化学, 2014 , 34(4) : 817 -820 . DOI: 10.6023/cjoc201311024

Abstract

This paper reports a simple method for the synthesis of α-acetoxyacetophenone derivatives from acetophenones using ZnO as a catalyst and iodobenzene diacetate as an oxidant. This transformation undergoes two processes: the oxidation of saturated sp3-C—H bond and the acetoxylation of C=C bond. The structures of products were confirmed by IR, 1H NMR and 13C NMR. In addition, a possible reaction mechanism was proposed.

Key words： iodobenzene diacetate; acetophenones; oxidation of saturated sp3-C—H bond; acetoxylation

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