7β-羟基表雄酮的选择性合成
收稿日期: 2014-07-06
修回日期: 2014-08-26
网络出版日期: 2014-09-12
基金资助
广西教育厅自然科学重点基金(No. 201202ZD059)资助项目.
Selective Synthesis of 7β-Hydroxyepiandrosterone
Received date: 2014-07-06
Revised date: 2014-08-26
Online published: 2014-09-12
Supported by
Project supported by the Natural Science Fundation of Education Department of Guangxi Province (No. 201202ZD059).
黄燕敏 , 刘亮 , 戚斌斌 , 赵丹丹 , 杨雷 , 甘春芳 , 崔建国 . 7β-羟基表雄酮的选择性合成[J]. 有机化学, 2015 , 35(1) : 241 -245 . DOI: 10.6023/cjoc201407007
The 7β-hydroxyepiandrosterone (4) is a kind of compound possessing strong anti-inflammatory properties. Using dehydroisoandrosterone as starting material, 3β-acetoxy-7-oxodehydroisoandrosterone (3) was obtained by acetylation and oxidization. In the presence of Ni2+, compound 3 was selectively reduced to give compound 4, its 7-epimer, 7α-hydroxyepi- androsterone (5) and byproduct 6. The condition of selective reduction was investigated further. The structures of all compounds were characterized by IR, NMR and MS techniques.
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