藤黄酸重排反应产物研究
收稿日期: 2014-10-28
修回日期: 2014-11-23
网络出版日期: 2014-12-09
基金资助
中央高校基本科研业务费专项资金(Nos. 13D110513, 2232012D3-03)资助项目.
Research of Rearrangement Products of Gambogic Acid
Received date: 2014-10-28
Revised date: 2014-11-23
Online published: 2014-12-09
Supported by
Project supported by the Fundamental Research Funds for the Central Universities (Nos. 13D110513, 2232012D3-03).
杨鑫 , 孙中强 , 邓云霞 , 邵志宇 . 藤黄酸重排反应产物研究[J]. 有机化学, 2015 , 35(4) : 917 -921 . DOI: 10.6023/cjoc201410037
Gambogic acid derivatives possess potent anti-tumor activities against various cancer cell lines. In a search for new anti-tumor organic compounds, rearrangement reaction of gambogic acid was explored. After microwave irradiation under acidic condition, two rearrangement products were isolated and their structures were determined unambiguously by spectroscopic techniques. Both of them were screened for their cytotoxicities against A549, HCT116 and MDA-MB-231, and showed high inhibitory effects on the cell lines.
Key words： gambogic acid; rearrangement reaction; spectroscopy; cytotoxicity
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