有机化学 ›› 2015, Vol. 35 ›› Issue (4): 917-921.DOI: 10.6023/cjoc201410037 上一篇    下一篇

研究简报

藤黄酸重排反应产物研究

杨鑫, 孙中强, 邓云霞, 邵志宇   

  1. 东华大学化学化工与生物工程学院 上海 201620
  • 收稿日期:2014-10-28 修回日期:2014-11-23 发布日期:2014-12-09
  • 通讯作者: 邵志宇 E-mail:zyshao@dhu.edu.cn
  • 基金资助:

    中央高校基本科研业务费专项资金(Nos. 13D110513, 2232012D3-03)资助项目.

Research of Rearrangement Products of Gambogic Acid

Yang Xin, Sun Zhongqiang, Deng Yunxia, Shao Zhiyu   

  1. College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620
  • Received:2014-10-28 Revised:2014-11-23 Published:2014-12-09
  • Supported by:

    Project supported by the Fundamental Research Funds for the Central Universities (Nos. 13D110513, 2232012D3-03).

藤黄酸能显著抑制多种人类肿瘤细胞的增殖, 在酸性环境中易发生重排反应, 其重排产物对肿瘤细胞也具有很强的抑制作用. 通过波谱技术确定了两个藤黄酸的重排反应产物的结构并归属了其波谱数据. 细胞毒活性测试显示, 两个重排产物对A549, HCT116和MDA-MB-231显示很强的抑制作用.

关键词: 藤黄酸, 重排反应, 波谱技术, 细胞毒活性

Gambogic acid derivatives possess potent anti-tumor activities against various cancer cell lines. In a search for new anti-tumor organic compounds, rearrangement reaction of gambogic acid was explored. After microwave irradiation under acidic condition, two rearrangement products were isolated and their structures were determined unambiguously by spectroscopic techniques. Both of them were screened for their cytotoxicities against A549, HCT116 and MDA-MB-231, and showed high inhibitory effects on the cell lines.

Key words: gambogic acid, rearrangement reaction, spectroscopy, cytotoxicity