铜催化的芳基酮及其衍生物氧化酰胺化合成α-酮酰胺的反应研究
收稿日期: 2015-02-07
修回日期: 2015-05-12
网络出版日期: 2015-05-26
基金资助
科技部973计划(No. 2012CBA01204)和国家自然科学基金(No. 21302084)资助项目.
Copper-Catalyzed Oxidative Amidation of Aryl Ketone and ItsDerivatives to Form α-Keto Amides
Received date: 2015-02-07
Revised date: 2015-05-12
Online published: 2015-05-26
Supported by
Project supported by the National Key Basic Research Program of Ministry of Science and Technology of China (No. 2012CBA01204) and the National Natural Science Foundation of China (No. 21302084).
龚久涵 , 朱正 , 卢林 , 郭生梅 , 蔡琥 . 铜催化的芳基酮及其衍生物氧化酰胺化合成α-酮酰胺的反应研究[J]. 有机化学, 2015 , 35(9) : 1917 -1922 . DOI: 10.6023/cjoc201502010
The oxidative amidation between aryl ketone and amine to form keto amide in water was studied. A variety of amides co-catalyzed by copper and iodine were efficiently synthesized using TBHP as an oxidant under room temperature. On the other hand, a copper-catalyzed C—C bond cleavage of β-keto ester and its derivatives to prepare α-keto amides under O2 atmosphere was also studied.
Key words： H2O; O2; aryl ketone; β-keto esters; α-keto amides
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