铁催化二级氯代烷烃与炔基格氏试剂的交叉偶联反应
收稿日期: 2015-10-26
修回日期: 2015-12-16
网络出版日期: 2016-01-04
基金资助
葛兰素史克(上海)医药研发有限公司与上海交通大学药学院联合培养项目.
Iron-Catalyzed Cross-Coupling of Secondary Alkyl Chloride and the Alkynes Grignard Reagent
Received date: 2015-10-26
Revised date: 2015-12-16
Online published: 2016-01-04
Supported by
Project supported by the Union-Education Program of Shanghai Jiao Tong University and the Research and Development Center of GlaxoSmithKline.
贾婉 , 赵立志 , 魏恒旭 , 朱林东 , 傅磊 , 陈蔚春 . 铁催化二级氯代烷烃与炔基格氏试剂的交叉偶联反应[J]. 有机化学, 2016 , 36(5) : 1060 -1064 . DOI: 10.6023/cjoc201510031
A green, practical and efficient iron-catalyzed, base free cross-coupling reaction of non-activated secondary alkyl halides with the alkynes Grignard reagent has been developed to afford a variety of alkyl alkynes in high yields, using iron(III) chlorides as catalyst. This approach is quick and easy to operate. It exhibits promising in industry since utilizing the low-cost iron as a catalyst instead of expensive palladium or nickel.
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