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2016 , Vol. 36 >Issue 5: 1122 - 1126

DOI: https://doi.org/10.6023/cjoc201512013

研究简报

氯甲基甲醚的高效合成及其一锅法保护羟基

  • 郑东青 ,
  • 曹伟 ,
  • 马海燕 ,
  • 丁凯
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  • a. 华东理工大学金属有机实验室 上海 200237;
    b. 中国科学院上海有机化学研究所 天然产物合成重点实验室 上海 200032

收稿日期: 2015-12-09

  修回日期: 2016-01-05

  网络出版日期: 2016-01-15

基金资助

国家自然科学青年科学基金(No.20902098)资助项目.

收起

Efficient Synthesis of Chloromethyl Methyl Ether and One-Pot Hydroxyl Protection

  • Zheng Dongqing ,
  • Cao Wei ,
  • Ma Haiyan ,
  • Ding Kai
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  • a. Laboratory of Organometallic, East China University of Science and Technology, Shanghai 200237;
    b. CAS Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032

Received date: 2015-12-09

  Revised date: 2016-01-05

  Online published: 2016-01-15

Supported by

Project supported by the National Natural Science Foundation for Young Scientists of China (No. 20902098).

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摘要

氯甲基甲醚(MOMCl)是一种有机合成中常用的保护基试剂.报道了一种快速、方便地合成MOMCl的方法.该方法具有反应条件温和,速度快、产率高、操作简单的特点,并可用于一锅法羟基保护过程.

关键词： 氯甲基甲醚; 羟基保护试剂; 一锅法

本文引用格式

郑东青 , 曹伟 , 马海燕 , 丁凯 . 氯甲基甲醚的高效合成及其一锅法保护羟基[J]. 有机化学, 2016 , 36(5) : 1122 -1126 . DOI: 10.6023/cjoc201512013

Abstract

Chloromethyl methyl ether (MOMCl) is an important protecting agent in organic synthesis. An efficient synthesis of chloromethyl methyl ether is reported and a one-pot hydroxyl protection procedure is developed. The method features mild condition, short reaction time, high yield and simple operation.

Key words： chloromethyl methyl ether; hydroxyl protecting agent; one-pot

参考文献

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