有机化学 ›› 2016, Vol. 36 ›› Issue (5): 1122-1126.DOI: 10.6023/cjoc201512013 上一篇    下一篇

研究简报

氯甲基甲醚的高效合成及其一锅法保护羟基

郑东青a, 曹伟a, 马海燕a, 丁凯b   

  1. a. 华东理工大学金属有机实验室 上海 200237;
    b. 中国科学院上海有机化学研究所 天然产物合成重点实验室 上海 200032
  • 收稿日期:2015-12-09 修回日期:2016-01-05 发布日期:2016-01-15
  • 通讯作者: 马海燕, 丁凯 E-mail:haiyanma@ecust.edu.cn;dingkai@mail.sioc.ac.cn
  • 基金资助:

    国家自然科学青年科学基金(No.20902098)资助项目.

Efficient Synthesis of Chloromethyl Methyl Ether and One-Pot Hydroxyl Protection

Zheng Dongqinga, Cao Weia, Ma Haiyana, Ding Kaib   

  1. a. Laboratory of Organometallic, East China University of Science and Technology, Shanghai 200237;
    b. CAS Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032
  • Received:2015-12-09 Revised:2016-01-05 Published:2016-01-15
  • Supported by:

    Project supported by the National Natural Science Foundation for Young Scientists of China (No. 20902098).

氯甲基甲醚(MOMCl)是一种有机合成中常用的保护基试剂.报道了一种快速、方便地合成MOMCl的方法.该方法具有反应条件温和,速度快、产率高、操作简单的特点,并可用于一锅法羟基保护过程.

关键词: 氯甲基甲醚, 羟基保护试剂, 一锅法

Chloromethyl methyl ether (MOMCl) is an important protecting agent in organic synthesis. An efficient synthesis of chloromethyl methyl ether is reported and a one-pot hydroxyl protection procedure is developed. The method features mild condition, short reaction time, high yield and simple operation.

Key words: chloromethyl methyl ether, hydroxyl protecting agent, one-pot