川西獐牙菜中两个新的链状单萜类化合物
收稿日期: 2016-03-23
修回日期: 2016-04-29
网络出版日期: 2016-06-01
基金资助
国家杰出青年科学基金（No.81025023）资助项目.
Two New Linear Monoterpenoids from Swertia mussotii
Received date: 2016-03-23
Revised date: 2016-04-29
Online published: 2016-06-01
Supported by
Project supported by the National Science Foundation of China for Distinguished Young Scholar (No.81025023).
利用多种色谱分离方法对川西獐牙菜的化学成分进行研究，从其全草的乙醇提取物中分离得到四个化合物，应用HR-ESIMS，1D和2D NMR，IR，UV等多种现代波谱技术确定了这些化合物的化学结构，经鉴定分别为（S，2E，6E）-2，6-二甲基-4，8-二羟基辛烷-2，6-二烯酸（1），（S，2E，6E）-2，6-二甲基-4-羟基-8-甲酰氧基辛烷-2，6-二烯酸（2），swerimilegenins B和C（3和4）.化合物1和2为两个新的链状单萜类化合物，分别命名为川西獐牙菜酸C和D，化合物3和4是两个不常见的C9骨架的环烯醚萜，为首次从该植物中分离得到.
曹团武 , 何康 , 耿长安 , 张雪梅 , 周俊 , 陈纪军 . 川西獐牙菜中两个新的链状单萜类化合物[J]. 有机化学, 2016 , 36(9) : 2216 -2219 . DOI: 10.6023/cjoc201603038
Investigation on Swertia mussotii resulted in four compounds by means of various chromatographic techniques (silica gel, Sephadex LH-20, RP-LC and Pre-HPLC). Their structures were determined as (S,2E,6E)-4,8-dihydroxy-2,6-dime-thylocta-2,6-dienoic acid (1), (S,2E,6E)-8-(formyloxy)-4-hydroxy-2,6-dimethylocta-2,6-dienoic acid (2), swerimilegenins B and C (3 and 4) on the basis of extensive spectroscopic analyses including MS, IR, UV, 1D- and 2D-NMR. Among them, compounds 1 and 2 are two new linear monoterpenoids named as swerimusic acids C (1) and D (2), compounds 3 and 4 are two unusual known secoiridoid aglycones of C9-skeleton obtained for the first time from this plant. Compounds 1~4 were evaluated for their anti-Hepatitis B Virus (HBV) activities on HepG2.2.15 cells line in vitro, but these compounds showed no anti-HBV activity at the maximal tesing concentration. Herin, we only report the isolation and structure elucidation of these compounds.
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