α-糜蛋白酶催化合成喹啉衍生物
收稿日期: 2016-04-24
修回日期: 2016-06-02
网络出版日期: 2016-07-07
基金资助
国家自然科学基金（Nos.21262002，21462001，21465002）、长江学者和创新团队发展计划（No.IRT13054）、江西省自然科学基金（No.20142BAB203008）资助项目.
Synthesis of Quinoline Derivatives Catalyzed by α-Chymotrypsin
Received date: 2016-04-24
Revised date: 2016-06-02
Online published: 2016-07-07
Supported by
Project supported by the National Natural Science Foundation of China (Nos.21262002,21462001,21465002),the Program for Changjiang Scholars and Innovative Research Team in University (No.IRT13054),the Natural Science Foundation of Jiangxi Province (No.20142BAB203008).
梁萌 , 谢宗波 , 艾锋 , 乐长高 . α-糜蛋白酶催化合成喹啉衍生物[J]. 有机化学, 2016 , 36(11) : 2704 -2708 . DOI: 10.6023/cjoc201604051
The α-chymotrypsin-catalyzed Friedländer condensation reaction between 2-aminoaryl ketone and α-methylene ketone was firstly reported, and a series of quinoline derivatives were obtained in moderate to excellent yields. This method is easy to operate and the reaction condition is mild, which not only expands the application of the promiscuity of protease, but also has positive significance for promoting the development of the green chemistry.
Key words： α-chymotrypsin; Friedlä; nder condensation; quinoline derivatives; biocatalysis
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