有机化学 ›› 2016, Vol. 36 ›› Issue (11): 2704-2708.DOI: 10.6023/cjoc201604051 上一篇    下一篇

研究论文

α-糜蛋白酶催化合成喹啉衍生物

梁萌b, 谢宗波a,b, 艾锋b, 乐长高a,b   

  1. a 东华理工大学 江西省质谱科学与仪器2011协同创新中心 南昌 330013;
    b 东华理工大学应用化学系 南昌 330013
  • 收稿日期:2016-04-24 修回日期:2016-06-02 发布日期:2016-07-07
  • 通讯作者: 谢宗波, 乐长高 E-mail:zhgle@ecit.cn;zbxie@ecit.cn
  • 基金资助:

    国家自然科学基金(Nos.21262002,21462001,21465002)、长江学者和创新团队发展计划(No.IRT13054)、江西省自然科学基金(No.20142BAB203008)资助项目.

Synthesis of Quinoline Derivatives Catalyzed by α-Chymotrypsin

Liang Mengb, Xie Zongboa,b, Ai Fengb, Le Zhanggaoa,b   

  1. a Jiangxi 2011 Joint Center for the Innovative Mass Spectrometry and Instrumentation, East China University of Technology, Nanchang 330013;
    b Department of Applied Chemistry, East China University of Technology, Nanchang 330013
  • Received:2016-04-24 Revised:2016-06-02 Published:2016-07-07
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos.21262002,21462001,21465002),the Program for Changjiang Scholars and Innovative Research Team in University (No.IRT13054),the Natural Science Foundation of Jiangxi Province (No.20142BAB203008).

首次以α-糜蛋白酶为生物催化剂,通过2-氨基芳基酮和α-亚甲基酮之间的Friedländer缩合反应,合成了11种喹啉衍生物,取得了中等至优异的产率.该方法操作简便,条件温和,不仅拓展了蛋白酶非专一性及生物催化的应用范围,对推动绿色化学的发展也具有积极意义.

关键词: α-糜蛋白酶, Friedlä, nder缩合反应, 喹啉衍生物, 生物催化

The α-chymotrypsin-catalyzed Friedländer condensation reaction between 2-aminoaryl ketone and α-methylene ketone was firstly reported, and a series of quinoline derivatives were obtained in moderate to excellent yields. This method is easy to operate and the reaction condition is mild, which not only expands the application of the promiscuity of protease, but also has positive significance for promoting the development of the green chemistry.

Key words: α-chymotrypsin, Friedlä, nder condensation, quinoline derivatives, biocatalysis