无催化条件下三组分一锅法合成呋喃并吡啶并喹喔啉衍生物
收稿日期: 2016-08-24
修回日期: 2016-12-24
网络出版日期: 2017-02-08
基金资助
江苏省高校重大基础自然科学基金（No.14KJA150004）、江苏师范大学校自然科学基金（No.15XLA05）资助项目.
One-Pot and Three-Component Synthesis of Furopyridoquinoxaline Derivatives under Catalyst-Free Conditions
Received date: 2016-08-24
Revised date: 2016-12-24
Online published: 2017-02-08
Supported by
Project supported by the Major Basic Natural Science Foundation of University in Jiangsu Province (No. 14KJA150004) and the Natural Science Foundation of Jiangsu Normal University (No. 15XLA05).
张梅梅 , 王洁 , 刘建全 , 王香善 . 无催化条件下三组分一锅法合成呋喃并吡啶并喹喔啉衍生物[J]. 有机化学, 2017 , 37(6) : 1565 -1570 . DOI: 10.6023/cjoc201608020
A series of 11-aryl-8,11-dihydrofuro[3',4':5,6]pyrido[3,2-f]quinoxalin-10(7H)-one derivatives were obtained via a one-pot and three-component reaction of aromatic aldehydes, 6-aminoquinoxaline and tetronic acid in EtOH. The structure of 11-(4-nitrophenyl)-8,11-dihydrofuro[3',4':5,6]pyrido[3,2-f]quinoxalin-10(7H)-one (4g) was confirmed by X-ray diffraction analysis. This procedure had the advantages of operation simplicity, catalyst-free and without isolating intermediates, and provided a good method for the synthesis of fused tetracyclic heterocycles containing furan, pyridine and quinoxaline moieties at the same time.
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