一锅法合成多取代色酮并双环吡啶类化合物
收稿日期: 2016-12-12
修回日期: 2017-01-21
网络出版日期: 2017-02-20
基金资助
国家自然科学基金（Nos.U1202221，21362042，21262042，21662042）、云南省后备人才（No.2012HB001）、云南大学青年英才计划（No.XT412003）资助项目.
One-Pot Synthesis of Multisubstituted Chromone-Fused Bicyclic Pyridine Compounds
Received date: 2016-12-12
Revised date: 2017-01-21
Online published: 2017-02-20
Supported by
Project supported by the National Natural Science Foundation of China (Nos. U1202221, 21362042, 21262042, 21662042), the Talent Found in Yunnan Province (No. 2012HB001), and the Excellent Young Talents of Yunnan University (No. XT412003).
陈亮 , 王保取 , 赵宇澄 , 严胜骄 , 林军 . 一锅法合成多取代色酮并双环吡啶类化合物[J]. 有机化学, 2017 , 37(6) : 1433 -1442 . DOI: 10.6023/cjoc201612038
A concise and environment friendly route for the synthesis of multisubstituted chromone-fused bicyclic pyridine compounds via one-step reaction of chromone-3-carboxaldehyde 1 and N-benzyl nitro ketene aminals (NBNKAs, 2) in ethanol media has been developed. The targeted compounds 3 can efficiently obtain by filter without extra post-treatment. The reaction is particularly attractive due to following features: low-cost and biocompatibility solvent, mild temperature, atom economy, high yields, and potential biological activity.
Key words： environment friendly; atom economy; catalyst-free; bicyclic pyridine; neonicotinoids
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