抗霉素A结构改造的研究进展
收稿日期: 2017-02-09
修回日期: 2017-03-03
网络出版日期: 2017-03-08
基金资助
国家自然科学基金（Nos.21472063，21502062）、湖北省教育厅一般项目（No.Q20102606）、襄阳市科技局一般项目（No.2010GG1B33）和低维光电材料与器件湖北省重点实验室（No.HLOM151005）资助项目.
Research Progress in Structural Modification of Antimycin A
Received date: 2017-02-09
Revised date: 2017-03-03
Online published: 2017-03-08
Supported by
Project supported by the National Natural Science Foundation of China (Nos. 21472063, 21502062), the Hubei Provincial Department of Education (No. Q20102606), the Xiangyang Science and Technology Bureau (No. 2010GG1B33), and the Hubei Key Laboratory of Low Dimensional Optoelectronic Materials and Devices (No. HLOM151005).
程华 , 聂忍 , 汪万强 , 黄琳 , 刘科 , 陈宬 , 吴琼友 . 抗霉素A结构改造的研究进展[J]. 有机化学, 2017 , 37(6) : 1368 -1381 . DOI: 10.6023/cjoc201702010
Antimycin A is a class of natural products bearing a dilactone-ring moiety as the core skeleton. These compounds have been identified as specific inhibitors of the mitochondrial respiratory chain and bind to the Qi site of the cytochrome bc1 complex. Due to its unique structure and extremly high activity, it has aroused great interest of researchers. The development and biological activities of antimycin A are mainly described, and the recent results of its structural modifications are summarized.
Key words： antimycin A; inhibitor; biological activity; structural modification
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