有机化学 ›› 2017, Vol. 37 ›› Issue (6): 1368-1381.DOI: 10.6023/cjoc201702010 上一篇    下一篇

综述与进展

抗霉素A结构改造的研究进展

程华a, 聂忍a, 汪万强a, 黄琳a, 刘科a, 陈宬c, 吴琼友b   

  1. a. 湖北文理学院化学化工与食品科学学院 襄阳 441053;
    b. 华中师范大学化学学院 农药与化学生物学教育部重点实验室 武汉 430079;
    c. 武汉理工大学材料复合新技术国家重点实验室 武汉 430070
  • 收稿日期:2017-02-09 修回日期:2017-03-03 发布日期:2017-03-08
  • 通讯作者: 吴琼友,陈宬 E-mail:qywu@mail.ccnu.edu.cn;chengchen@whut.edu.cn
  • 基金资助:

    国家自然科学基金(Nos.21472063,21502062)、湖北省教育厅一般项目(No.Q20102606)、襄阳市科技局一般项目(No.2010GG1B33)和低维光电材料与器件湖北省重点实验室(No.HLOM151005)资助项目.

Research Progress in Structural Modification of Antimycin A

Cheng Huaa, Nie Rena, Wang Wanqianga, Huang Lina, Liu Kea, Chen Chengc, Wu Qiongyoub   

  1. a. Department of Chemical Engineering and Food Science, Hubei Universtry of Arts and Science, Xiangyang 441053;
    b. Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079;
    c. State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070
  • Received:2017-02-09 Revised:2017-03-03 Published:2017-03-08
  • Contact: 10.6023/cjoc201702010 E-mail:qywu@mail.ccnu.edu.cn;chengchen@whut.edu.cn
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21472063, 21502062), the Hubei Provincial Department of Education (No. Q20102606), the Xiangyang Science and Technology Bureau (No. 2010GG1B33), and the Hubei Key Laboratory of Low Dimensional Optoelectronic Materials and Devices (No. HLOM151005).

抗霉素A (Antimycin A)是一类具有大环双内酯结构的天然产物,是典型的线粒体呼吸链细胞色素bc1复合物Qi位点抑制剂.鉴于该类化合物的独特结构与超高活性,越来越多的科研工作者对其展开了系统深入的研究.本文主要总结了Antimycin A的发现、生物活性研究,及近年来科研工作者对其进行结构改造所取得的成果.

关键词: 抗霉素A, 抑制剂, 生物活性, 结构改造

Antimycin A is a class of natural products bearing a dilactone-ring moiety as the core skeleton. These compounds have been identified as specific inhibitors of the mitochondrial respiratory chain and bind to the Qi site of the cytochrome bc1 complex. Due to its unique structure and extremly high activity, it has aroused great interest of researchers. The development and biological activities of antimycin A are mainly described, and the recent results of its structural modifications are summarized.

Key words: antimycin A, inhibitor, biological activity, structural modification