伯氏致病杆菌Xenorhabdus bovienii SN52中两个新的Rhabduscin类似物
收稿日期: 2017-02-20
修回日期: 2017-03-08
网络出版日期: 2017-03-14
基金资助
辽宁省攀登学者2012资助项目.
Two New Rhabduscin Analogues from Xenorhabdus bovienii SN52
Received date: 2017-02-20
Revised date: 2017-03-08
Online published: 2017-03-14
Supported by
Project supported by the Liaoning Pandeng Scholar Program in 2012.
采用硅胶柱层析、凝胶柱层析和半制备高效液相色谱技术对伯氏致病杆菌Xenorhabdus bovienii SN52的次生代谢产物进行分离纯化，得到2个新的rhabduscin类似物. 通过NMR和HR-ESI-MS等波谱技术和相关文献数据对照确定了它们的结构为4-O-（4-乙酰胺-β-L-鼠李糖苷）-苯甲醛（1）和4-O-（4-乙酰胺-β-L-鼠李糖苷）-（Z）-N-苯乙烯基甲酰胺（2）. 同时对化合物1和2的昆虫酚氧化酶抑制活性进行了评价.
关键词： 伯氏致病杆菌; rhabduscin类似物; 结构鉴定; 酚氧化酶活性
张文波 , 石丹姝 , 张春珍 , 于志国 . 伯氏致病杆菌Xenorhabdus bovienii SN52中两个新的Rhabduscin类似物[J]. 有机化学, 2017 , 37(4) : 996 -999 . DOI: 10.6023/cjoc201702027
Two new rhabduscin analogues were isolated and purified from fermentation broth of Xenorhabdus bovienii SN52 by silica gel column chromatography, sephadex LH-20 chromatography and high performance preparative liquid chromatography. On the basis of spectroscopic methods (HR-ESIMS, 1D- and 2D-NMR) and by comparison with those reported previously, their structures were identified as 4-O-(4-acetamide-β-L-rhamnoside)-benzaldehyde (1) and 4-O-(4-acetamide-β-L- rhamnoside)-(Z)-N-styrylforma mide (2). Their inhibitory activities against phenoloxidase were also tested.
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