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2018 , Vol. 38 >Issue 3: 710 - 714

DOI: https://doi.org/10.6023/cjoc201709008

研究简报

大果榕根中异黄酮类成分的研究

  • 邵泰明 ,
  • 李小宝 ,
  • 祁翠翠 ,
  • 陈光英 ,
  • 宋小平 ,
  • 韩长日 ,
  • 郑彩娟
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  • a 海南师范大学热带药用植物化学教育部重点实验室 海南师范大学化学与化工学院 海口 571158;
    b 海南省药食同源植物资源重点实验室 海南科技职业学院化学与材料工程学院 海口 571126

收稿日期: 2017-09-06

  修回日期: 2017-10-12

  网络出版日期: 2017-11-15

基金资助

国家自然科学基金（Nos.81360478，21362009）、国家国际科技合作专项（No.2014DFA40850）、海南省中药现代化专项（No.2015ZY19）、海南省重点研发计划项目-社会发展（No.ZDYF2016139）、海南省自然科学基金（No.217177）、海南科技职业学院校中青年基金（No.HKYZQJ2014-07）、海南省研究生创新科研课题（No.Hyb2017-33）资助项目.

收起

Chemical Constituents of Isoflavonoids from Roots of Ficus auriculata

  • Shao Taiming ,
  • Li Xiaobao ,
  • Qi Cuicui ,
  • Chen Guangying ,
  • Song Xiaoping ,
  • Han Changri ,
  • Zheng Caijuan
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  • a Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571127;
    b Key Laboratory of Medicinal and Edible Plants Resources of Hainan Province, School of Chemical and Material Engineering, Hainan Institute of Science and Technology, Haikou 571126

Received date: 2017-09-06

  Revised date: 2017-10-12

  Online published: 2017-11-15

Supported by

Project supported by the National Natural Science Foundation of China (Nos. 81360478, 21362009), the International S&T Cooperation Program of China (No. 2014DFA40850), the Hainan Special Project for Traditional Chinese Medicine Modernization (No. 2015ZY19), Key Research and Development Project of Hainan Province (No. ZDYF2016139), the Natural Science Foundation of Hainan Province (No. 217177), the Youth Foundation of Hainan Institute of Science and Technology (No. HKYZQJ2014-07), the Hainan Province Innovation Research Project of Graduate Students (No. Hyb2017-33).

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摘要

利用硅胶、高效液相等多种色谱技术对大果榕根的化学成分进行系统研究，从中分离得到5个异黄酮类化合物，根据理化性质、NMR、IR、UV-Vis等多种现代波谱技术鉴定上述化合物分别为5，7，4'-三羟基-8-（1-羟基-2，3-环氧-3-甲基丁基）异黄酮（1），5，7，4'-三羟基-3'-（2，6，7-三羟基-3-亚甲基-7-甲基辛基）异黄酮（2），5，7，4'-三羟基-6-[（S）-2，3-二羟基-3-甲基丁基]异黄酮（3），5，7，4'-三羟基-6-异戊烯基异黄酮（4），5，7，4'-三羟基-3'-异戊烯基-异黄酮（5）.其中化合物1和2为新化合物，对化合物1~5进行体外抗骨质疏松活性测试，结果表明化合物4和5在100 μmol/L时具有一定的抗骨质疏松活性.

关键词： 大果榕; 化学成分; 异黄酮; 抗骨质疏松活性

本文引用格式

邵泰明 , 李小宝 , 祁翠翠 , 陈光英 , 宋小平 , 韩长日 , 郑彩娟 . 大果榕根中异黄酮类成分的研究[J]. 有机化学, 2018 , 38(3) : 710 -714 . DOI: 10.6023/cjoc201709008

Abstract

Five isoflavonoids were isolated from the roots of the Ficus auriculata by means of silica gel column, HPLC and other chromatography methods. By using spectroscopic techniques including NMR, IR and UV, their structures were identified as 5,7,4'-trihydroxy-8-(1-hydroxy-2,3-epoxy-3-methylbutyl)isoflavone (1), 5,7,4'-trihydroxy-3'-(2,6,7-trihydroxy-3-methylene-7-methyloctyl)isoflavone (2), 5,7,4'-trihydroxy-6-[(S)-2,3-dihydroxy-3-methylbutyl]isoflavone (3), 5,7,4'-trihydroxy-6-pre-nylisoflavone (4), and 5,7,4'-trihydroxy-3'-prenylisoflavone (5). Compounds 1 and 2 were new isoflavonoids. All compounds were evaluated for their anti osteoporosis activities in vitro. Compounds 4 and 5 showed moderate proliferation function of primary osteoblasts in 100 μmol/L.

Key words： Ficus auriculata; chemical constituent; isoflavone; anti osteoporosis activity

参考文献

[1] Chinese Flora Editorial Board of Chinese Academy of Sciences Flora of China, Vol. 23, Science Press, Beijing, 1998, p. 170(in Chinese). (中国科学院中国植物志编委会, 中国植物志, 第23卷, 科学出版社, 北京, 1998, p. 170.)
[2] Institute of Medicinal Plant Development Hainan Branch Species List of South China Medicinal Plant Garden, China Agriculture Press, Beijing, 2007, p. 150(in Chinese). (中国医学科学院药用植物研究所海南分所, 南药园植物名录,中国农业出版社, 北京, 2007. p. 150.)
[3] Chiang, Y. M.; Chang, J. Y.; Kuo, C. C.; Kuo, Y. H. Phy-tochemistry 2005, 66, 495.
[4] Parveen, M.; Ghalib, R. M.; Mehdi, S. H.; Rehman, S. H.; Ali, M. Nat. Prod. Res. 2009, 23, 729.
[5] Parveen, M.; Ghalib, R. M.; Mehdi, S. H.; Mattu, R. U. H.; Ali, M. J. Saudi. Chem. Soc. 200913, 287.
[6] Bankeu, J. J. K.; Khayala, R.; Lenta, B. N.; Noungoue, D. T.; Ngouela, A. A. J. Nat. Prod. 2011, 74, 1370.
[7] Kiem, P. V.; Coung, N. X.; Nhiem, N. X.; Thu, V. T.; Ban, N. K.; Tai, B. H.; Kim, Y. H. Bioorg. Med. Chem. Lett. 2011, 21, 633.
[8] Zaffer, B. M.; Mohd, A.; Rasool, M. S. Int. Res. J. Pharm. 2012, 3, 140.
[9] Shao, T. M.; Zheng, C. J.; Han, C. R.; Chen, G. Y.; Dai, C. Y.; Song, X. P.; Zhang, J. C.; Chen, W. H. Bioorg. Med. Chem. Lett. 2014, 24, 3952.
[10] Shao, T. M.; Song, X. P.; Chen, G. Y.; Han, C. R.; Zheng, C. J.; Yao, G. G. Chin. Tradit. Herb. Drug 2013, 44, 2208(in Chinese). (邵泰明, 宋小平, 陈光英, 韩长日, 郑彩娟, 姚国贵, 中草药, 2013, 44, 2208.)
[11] Shao, T. M.; Song, X. P.; Han, C. R.; Chen, G. Y.; Chen, W. H.; Dai, C. Y.; Song, X. M. Nat. Prod. Res. Dev. 2013, 25, 624(in Chinese). (邵泰明, 宋小平, 韩长日, 陈光英, 陈文豪, 戴春燕, 宋鑫明, 天然产物研究与开发, 2013, 25, 624.)
[12] Tian, X. M.; Chen, S. Z.; Tang, L.; Peng, F. T. Helv. Chim. Acta 2008, 91, 1015.
[13] Matsuda, H.; Mofikawa, T.; Xu, F. M.; Ninomiya, K.; Yo-shikawa, M. Planta Med. 2004, 70, 1201.
[14] Li, X. L.; Wang, N. L.; Zhang, X.; Yao, X. S. J. Shenyang Pharm. Univ. 2005, 122, 189(in Chinese). (李晓莉, 王乃利, 张雪, 姚新生, 沈阳药科大学学报, 2005, 122, 189.)
[15] Jiang, B.; Han, W. L.; Zhang, Q. W.; Zhang, X. Q.; Ye, W. C. J. Chin. Med. Mater. 2012, 35, 904(in Chinese). (江蓓, 韩伟立, 张庆文, 张晓琦, 叶文才, 中药材, 2012, 35, 904.)
[16] Moamann, T. J. Immunol. Methods 1983, 65, 55.

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