(S)-联萘酚钛体系催化3-噻吩铝试剂对酮的不对称加成反应
收稿日期: 2017-10-07
修回日期: 2017-11-09
网络出版日期: 2017-11-17
基金资助
国家自然科学基金（Nos.21372009，21672004）资助项目.
Asymmetric Addition of 3-Thienyl Aluminum to Ketones Catalyzed by the Simple Titanium Catalytic System of (S)-1,1'-Binaphthol
Received date: 2017-10-07
Revised date: 2017-11-09
Online published: 2017-11-17
Supported by
Project supported by the National Natural Science Foundation of China (Nos. 21372009, 21672004).
戈敏 , 张丽军 , 涂兵 , 周双六 . (S)-联萘酚钛体系催化3-噻吩铝试剂对酮的不对称加成反应[J]. 有机化学, 2018 , 38(3) : 672 -676 . DOI: 10.6023/cjoc201710004
The optically active diaryl alcohols bearing thienyl group are well-known for their biological activity as well as key substructure in bioactive compounds and pharmaceuticals. The asymmetric addition of 3-thienyl aluminum to ketones afforded the optically active 3-thienyl arylethanols in good yields with high enantioselectivities of up to 91% ee employing the simple titanium catalytic system of (S)-1,1'-binaphthol. The catalytic system could also suit for various ketones bearing an electron-donating or electron-withdrawing groups to afford the corresponding diarylethanols containing substituted 3-thienyl groups.
Key words： asymmetric synthesis; thienyl; aluminum; titanium; ketones
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