研究论文

增强型超分子荧光探针对拉帕替尼的识别及其在细胞成像中的应用

  • 王成会 ,
  • 唐青 ,
  • 席芸芸 ,
  • 杨梅 ,
  • 李涛 ,
  • 黄英 ,
  • 陶朱
展开
  • a 贵州大学西南药用生物资源教育部工程研究中心 贵阳 550025;
    b 贵州大学贵州省大环化学及超分子化学重点实验室 贵阳 550025;
    c 贵州大学烟草学院 贵阳 550025

收稿日期: 2017-11-09

  修回日期: 2018-01-19

  网络出版日期: 2018-03-08

基金资助

国家自然科学基金(No.21562015)、贵州省优秀青年科技人才培养计划(No.[2017]5636)、贵州省科学技术基金(No.[2014]2005)、贵州省普通高等学校科技拔尖人才支持计划(No.[2016]059)、贵州省科技厅联合基金(No.[2014]7658)、贵州大学研究生创新基金(No.2017001)资助项目.

A Turn-On Supramolecular Fluorescent Probe for Sensing Lapatinib and Its Application in Living Cell Imaging

  • Wang Chenghui ,
  • Tang Qing ,
  • Xi Yunyun ,
  • Yang Mei ,
  • Li Tao ,
  • Huang Ying ,
  • Tao Zhu
Expand
  • a Engineering and Research Center for Southwest Bio-pharmaceutical Resources of National Education Ministry of China, Guizhou University, Guiyang 550025;
    b Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province, Guizhou University, Guiyang 550025;
    c College of Tobacco Science, Guizhou University, Guiyang 550025

Received date: 2017-11-09

  Revised date: 2018-01-19

  Online published: 2018-03-08

Supported by

Project supported by the National Natural Science Foundation of China (No. 21562015), the Excellent Youth Scientific Talents Foundation of Guizhou Province (No.[2017]5636), the Natural Science Fund of the Science and Technology Department of Guizhou Province (No. JZ-2014-2005), the Talents Support Project of Guizhou Province of Education (No. QJH-KY-2016-059), the Joint Funds Plan from the Science and Technology Department of Guizhou Province (No. QKH-LH-2014-7658), and the Graduate Student Innovative Funding of Guizhou University (No. 2017001).

摘要

通过超分子识别设计了八元瓜环与派洛宁Y超分子荧光探针2PyY@Q[8],研究了该探针对抗癌药物拉帕替尼的识别性质.研究结果表明,该探针在水溶液中对拉帕替尼具有良好的识别能力及选择性,在一定浓度范围内其线性关系良好,其检出限为1.44×10-8 mol/L.细胞成像结果显示该探针在前列腺癌细胞中对拉帕替尼具有很好的响应,可用于生物细胞内拉帕替尼的识别检测.

本文引用格式

王成会 , 唐青 , 席芸芸 , 杨梅 , 李涛 , 黄英 , 陶朱 . 增强型超分子荧光探针对拉帕替尼的识别及其在细胞成像中的应用[J]. 有机化学, 2018 , 38(6) : 1394 -1400 . DOI: 10.6023/cjoc201711018

Abstract

aEngineering and Research Center for Southwest Bio-pharmaceutical Resources of National Education Ministry of China, Guizhou University, Guiyang 550025) (bKey Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province, Guizhou University, Guiyang 550025) (cCollege of Tobacco Science, Guizhou University, Guiyang 550025

参考文献

[1] U S FDA. FDA approves Tykerb for advanced breast cancer patients[EB/OL].[2007-06-25]. http://www.fda.gov/bbs/topics/NEWS/2007/NEW01586.html.
[2] Devriese, L. A.; Koch, K. M.; Mergui-Roelvink, M.; Matthys, G. M.; Ma, W. W.; Robidoux, A.; Stephenson, J. J.; Chu, Q. S. C.; Oford, K. W.; Cartee, L.; Bothyl, J.; Arya, N.; Schellens, J. H. M. Invest. New Drugs 2014,32,481.
[3] Zhao, S.-J.; Zhu, Z. Chin. Pharm. J. 2008, 43, 1037(in Chinese) (赵胜军, 朱珠, 中国药学杂志, 2008, 43, 1037.)
[4] Feng, H.-R.; Li, Q.; Wang, H. L. Prog. Mod. Biomed. 2012, 12, 746(in Chinese). (冯焕荣, 李青, 王海琳, 现代生物医学进展, 2012, 12, 746.)
[5] Ohgami, M.; Homma, M.; Suzuki, Y.; Naito, K.; Yamada, M.; Mitsuhashi, S.; Fujisawa, F.; Kojima, H.; Kaburagi, T.; Uchiumi, K.; Yamada, Y.; Bando, H.; Hara, H.; Takei, K. Ther. Drug Monit. 2016, 6, 657.
[6] Roche, S.; McMahon, G.; Clynes, M.; O'Connor, R. J. Chromatogr. B 2009, 877, 3982.
[7] Lankheet, N. A.; Hillebrand, M. J.; Rosing, H.; Schellens, J. H.; Beijnen, J. H.; Huitema, A. D. Biomed. Chromatogr. 2013, 27, 466.
[8] Escudero-Ortiz, V.; Perez-Ruixo, J. J.; Valenzuela, B. Ther. Drug Monit. 2013, 6, 796.
[9] Liu, Y.; Ji, D. K.; Dong, L.; Galanos, N.; Zang, Y.; Li, J.; Vidal, S.; He, X. P. Chem. Commun. 2017, 53, 11937.
[10] Xu, M.; Wu, S.; Zeng, F.; Yu, C. Langmuir 2010, 26, 4529.
[11] Chen, Y.; Han, K. Y.; Liu, Y. Bioorg. Med. Chem. 2007, 15, 4537.
[12] Wang, K.; Guo, D. S.; Wang, X.; Liu, Y. ACS Nano 2011, 5, 2880.
[13] Valeur, B.; Leray, I. Inorg. Chim. Acta 2007, 360, 765.
[14] Ji, H. F.; Dabestani, R.; Brown, G. M. J. Am. Chem. Soc. 2000, 122, 9306.
[15] Leray, I.; Valeur, B. Eur. J. Inorg. Chem. 2009, 3525.
[16] Nau, W. M.; Ghale, G.; Hennig, A.; Bakirci, H.; Bailey, D. M. J. Am. Chem. Soc. 2009, 131, 11558.
[17] Li, F. S.; Xu, Y. Q.; Li, H. J.; Wang, C. X.; Lu, A. P.; Sun, S. G. New J. Chem. 2014, 38, 1396.
[18] Florea, M.; Nau, W. M. Angew. Chem., Int. Ed. 2011, 50, 9338.
[19] Dsouza, R. N.; Pischel, U.; Nau, W. M. Chem. Rev. 2011, 111, 7941.
[20] Hennig, A.; Bakirci, H.; Nau, W. M. Nat. Methods 2007, 4, 629.
[21] Sindelar, V.; Cejas, M. A.; Raymo, F. M.; Chen, W.; Parker, S. E.; Kaifer, A. E. Chem.-Eur. J. 2005, 11, 7054.
[22] Montes-Navajas, P.; Corma, A.; Garcia, H. ChemPhysChem 2008, 9, 713.
[23] Xi, Y.-Y.; Tang, Q.; Huang, Y.; Zhu, T.; Xue, S. F.; Zhu, Q. J. J. Guizhou Univ. (Nat. Sci.) 2016, 33, 35(in Chinese). (席芸芸, 唐青, 黄英, 陶朱, 薛赛凤, 祝黔江, 贵州大学学报(自然科学版), 2016, 33, 35.)
[24] Kim, H. J.; Heo, J.; Jeon, W. S.; Lee, E.; Kim, J.; Sakamoto, S.; Yamaguchi, K.; Kim, K. Angew. Chem., Int. Ed. 2001, 40, 1526.
[25] Baumes, L. A.; Sogo, M. B.; Navajas, P. M.; Corma, A.; Garcia, H. Tetrahedron Lett. 2009, 50, 7001.
[26] Baumes, L. A.; Buaki, M.; Jolly, J.; Corma, A.; Garcia, H. Tetrahedron Lett. 2011, 52, 1418.
[27] Moon, K.; Grindstaff, J.; Sobransingh, D.; Kaifer, A. E. Angew. Chem., Int. Ed. 2004, 43, 5496.
[28] Wang, W.; Kaifer, A. E. Angew. Chem., Int. Ed. 2006, 45, 7042.
[29] Day, A. I.; Blanch, R. J.; Arnold, A. P.; Lorenzo, S.; Lewis, G. R.; Dance, I. Angew. Chem., Int. Ed. 2002, 41, 275.
[30] Kubin, R. F.; Fletcher, A. N. J Lumin. 1982, 27, 455.
[31] Kubota, Y.; Steiner, R. F. Biophys. Chem. 1977, 6, 279.

文章导航

/