氯化胆碱催化醛、吲哚和丙二腈的三组分Yonemitsu缩合反应
收稿日期: 2018-03-05
修回日期: 2018-05-31
网络出版日期: 2018-06-07
基金资助
国家自然科学基金（No.21403100）和国家级大学生创新创业训练计划（No.201710165304）资助项目.
Choline Chloride as Catalyst towards the Attractive Yonemitsu Reaction of Benzaldehyde, Indole, and Malononitrile
Received date: 2018-03-05
Revised date: 2018-05-31
Online published: 2018-06-07
Supported by
Project supported by the National Natural Science Foundation of China (No. 21403100), the National Students Program for Innovation and Entrepreneurship Training (No. 201710165304).
杨中华, 刘兰野, 赵益鹤, 洪远琳, 阮鸿力, 吕成伟 . 氯化胆碱催化醛、吲哚和丙二腈的三组分Yonemitsu缩合反应[J]. 有机化学, 2018 , 38(10) : 2761 -2766 . DOI: 10.6023/cjoc201803007
Using choline chloride as cheap and safe accelerator was efficient to promote the Yonemitsu type condensation of indole, benzaldehyde, and malononitrile. More importantly, introducing right amount of water in reaction system was crucial to get desired 3-substituted indoles in good to excellent yields. Due to the catalyst has excellent solubility in aqueous ethanol, the final concoction was easy to separate. Many desired products could be obtained after filtration and washed with cold aqueous ethanol without further purification. Catalyst could further reuse for five more reaction cycles with negligible loss in activity.
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