氨基酸三唑锰催化苯醌甲基化物的偶联反应研究
收稿日期: 2018-05-08
修回日期: 2018-07-18
网络出版日期: 2018-08-14
基金资助
国家自然科学基金（No.21776111）和中央高校自主科研（No.JUSRP51627B）资助项目.
Alanine Triazole Mn-Catalyzed Coupling/Aromatization of Quinone Methides
Received date: 2018-05-08
Revised date: 2018-07-18
Online published: 2018-08-14
Supported by
Project supported by the National Natural Science Foundation of China (No. 2176111), the Fundamental Research Funds for the Central Universities (No. JUSRP 51627B).
胡昕宇 , 杨伯斌 , 姚玮 , 王大伟 . 氨基酸三唑锰催化苯醌甲基化物的偶联反应研究[J]. 有机化学, 2018 , 38(12) : 3296 -3301 . DOI: 10.6023/cjoc201805019
Alanine triazole Mn-catalyzed 1,6-conjugate coupling/aromatization of para-quinone methides was developed with good to high yields under mild conditions. This protocol provided an efficient and practical route to the synthetically interesting functionalized methines and their analogues. Preliminary mechanistic experiments revealed 1,6-conjugate addition of nucleophiles to para-quinone methides (p-QMs). The manganese was acted as the Lewis acid.
Key words： quinone methide; manganese; ligand; triazole
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