Sc(Ⅲ)催化胺对邻亚甲基苯醌氮杂迈克尔加成反应合成贝蒂碱衍生物
收稿日期: 2018-08-31
修回日期: 2018-11-09
网络出版日期: 2018-11-26
基金资助
山东省山东省科学院青年科学基金（No.2018QN0030）和国家自然科学基金（No.51503118）资助项目.
Scandium(III)-Catalyzed Aza-Michael Addition of in Situ Generated ortho-Quinone Methides with Amines: An Efficient Access to Betti Base Derivatives
Received date: 2018-08-31
Revised date: 2018-11-09
Online published: 2018-11-26
Supported by
Project supported by the Shandong Provincial Natural Science Foundation (No. ZR2017BB033), the Youth Science Funds of Shandong Academy of Sciences (No. 2018QN0030) and the National Natural Science Foundation of China (No. 51503118).
张硕 , 赵宁 , 李庆刚 , 张嘉祺 , 侯梓桐 , 刘一帆 , 于一涛 , 彭丹 , 王峰 , 李冰 , 李金辉 . Sc(Ⅲ)催化胺对邻亚甲基苯醌氮杂迈克尔加成反应合成贝蒂碱衍生物[J]. 有机化学, 2019 , 39(3) : 709 -719 . DOI: 10.6023/cjoc201808045
o-Quinone derivatives are not only a variety of active and important intermediate, but also widely used in the synthesis of natural products and medicinal chemistry. In the present study, the Sc(Ⅲ) catalyzed aza-Michael addition to o-quinone methides by amines for the synthesis of Betti base derivatives was developed. The reaction was performed in a sealed tube at 90℃ for 4 h and the products were obtained in moderate to good yields (76%~96%).
Key words： o-quinone; Betti base; aza-Michael addtion; green chemistry
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