1,4-二氮杂二环[2.2.2]辛烷(DABCO)催化联烯的[4+2]串联反应:合成苯并噻吩并吡喃衍生物
收稿日期: 2019-04-30
修回日期: 2019-06-25
网络出版日期: 2019-07-09
基金资助
国家自然科学基金（No.21403154）、天津市自然科学基金（No.17JCZDJC37700）、天津市教育委（No.20180KJ137）资助项目.
1,4-Diazabicyclo[2.2.2]octane (DABCO)-Catalyzed [4+2] Domino Reaction of Allenoates: Synthesis of Benzo[4,5]thieno-[3,2-b]pyran Derivatives
Received date: 2019-04-30
Revised date: 2019-06-25
Online published: 2019-07-09
Supported by
Project supported by the National Natural Science Foundation of China (No. 21403154), the Natural Science Foundation of Tianjin City (No. 17JCZDJC37700) and the Tianjin Municipal Education Commission (No. 20180KJ137).
贾继茹 , 于爱敏 , 刘旭光 , 孟祥太 . 1,4-二氮杂二环[2.2.2]辛烷(DABCO)催化联烯的[4+2]串联反应:合成苯并噻吩并吡喃衍生物[J]. 有机化学, 2019 , 39(8) : 2175 -2182 . DOI: 10.6023/cjoc201904082
A 1,4-diazabicyclo[2.2.2]octane (DABCO)-catalyzed[4+2] annulation reaction between 2-alkylidenebenzothio phene-3(2H)-ones and allenoate has been developed. The substrate scope includes both electron-withdrawing and electron-donating groups on the benzothiophene moiety. This method can be carried out under mild conditions and gives a wide range of highly functionalized benzothiophene-fused γ-pyran derivatives in good yields with moderate selectivity.
Key words： domino reaction; allenoate; benzothiophene derivatives
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