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2020 , Vol. 40 >Issue 1: 156 - 161

DOI: https://doi.org/10.6023/cjoc201905040

研究论文

深共融溶剂中合成2,4-二取代喹啉衍生物

  • 陈国庆 ,
  • 谢宗波 ,
  • 刘一帅 ,
  • 孟佳 ,
  • 乐长高
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  • a 东华理工大学核资源与环境国家重点实验室 南昌 330013;
    b 东华理工大学应用化学系 南昌 330013

收稿日期: 2019-05-19

  修回日期: 2019-07-20

  网络出版日期: 2019-09-05

基金资助

国家自然科学基金（Nos.21462001，11765002）、江西省科技计划（Nos.20161BCB24006，20181BAB203019）资助项目.

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Synthesis of 2,4-Disubstituted Quinolines in Deep Eutectic Solvents

  • Chen Guoqing ,
  • Xie Zongbo ,
  • Liu Yishuai ,
  • Meng Jia ,
  • Le Zhanggao
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  • a State Key Laboratory of Nuclear Resources and Environment, East China University of Technology, Nanchang 330013;
    b Department of Applied Chemistry, East China University of Technology, Nanchang 330013

Received date: 2019-05-19

  Revised date: 2019-07-20

  Online published: 2019-09-05

Supported by

Project supported by the National Natural Science Foundation of China (Nos. 21462001, 11765002), and the Science and Technology Projects of Jiangxi Province (Nos. 20161BCB24006, 20181BAB203019).

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摘要

在氯化胆碱和氯化锌组成的深共融溶剂中，以2-氨基苯乙酮和芳香炔烃为原料，通过环化偶联反应，合成了一系列2，4-二取代喹啉衍生物；当n（氯化胆碱）：n（氯化锌）=1：2，反应温度为80℃时，反应3 h即获得高达98%的产率.该方法无需额外添加催化剂，而且反应条件温和、操作简单、底物范围较广泛.

关键词： 深共融溶剂; 氯化胆碱; 氯化锌; 环化偶联; 2,4-二取代喹啉

本文引用格式

陈国庆 , 谢宗波 , 刘一帅 , 孟佳 , 乐长高 . 深共融溶剂中合成2,4-二取代喹啉衍生物[J]. 有机化学, 2020 , 40(1) : 156 -161 . DOI: 10.6023/cjoc201905040

Abstract

In the deep eutectic solvent which composed of choline chloride and zinc chloride, a series of 2,4-disubstituted quinolines were synthesized via cyclization coupling of 2-aminoacetophenone and aromatic alkyne. When the molar ratio of choline chloride and zinc chloride was 1:2, the yield up to 98% was achieved at 80℃ for 3 h. The method does not need additional catalyst, and has the advantages of mild reaction conditions, simple operation and a wide range of substrates.

Key words： deep eutectic solvent; choline chloride; zinc chloride; cyclization coupling; 2,4-disubstituted quinoline

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