有机化学 ›› 2020, Vol. 40 ›› Issue (1): 156-161.DOI: 10.6023/cjoc201905040 上一篇    下一篇

研究论文

深共融溶剂中合成2,4-二取代喹啉衍生物

陈国庆a,b, 谢宗波a,b, 刘一帅b, 孟佳b, 乐长高a,b   

  1. a 东华理工大学核资源与环境国家重点实验室 南昌 330013;
    b 东华理工大学应用化学系 南昌 330013
  • 收稿日期:2019-05-19 修回日期:2019-07-20 发布日期:2019-09-05
  • 通讯作者: 谢宗波, 乐长高 E-mail:zbxie@ecut.edu.cn;zhgle@ecut.edu.cn
  • 基金资助:
    国家自然科学基金(Nos.21462001,11765002)、江西省科技计划(Nos.20161BCB24006,20181BAB203019)资助项目.

Synthesis of 2,4-Disubstituted Quinolines in Deep Eutectic Solvents

Chen Guoqinga,b, Xie Zongboa,b, Liu Yishuaib, Meng Jiab, Le Zhanggaoa,b   

  1. a State Key Laboratory of Nuclear Resources and Environment, East China University of Technology, Nanchang 330013;
    b Department of Applied Chemistry, East China University of Technology, Nanchang 330013
  • Received:2019-05-19 Revised:2019-07-20 Published:2019-09-05
  • Supported by:
    Project supported by the National Natural Science Foundation of China (Nos. 21462001, 11765002), and the Science and Technology Projects of Jiangxi Province (Nos. 20161BCB24006, 20181BAB203019).

在氯化胆碱和氯化锌组成的深共融溶剂中,以2-氨基苯乙酮和芳香炔烃为原料,通过环化偶联反应,合成了一系列2,4-二取代喹啉衍生物;当n(氯化胆碱):n(氯化锌)=1:2,反应温度为80℃时,反应3 h即获得高达98%的产率.该方法无需额外添加催化剂,而且反应条件温和、操作简单、底物范围较广泛.

关键词: 深共融溶剂, 氯化胆碱, 氯化锌, 环化偶联, 2,4-二取代喹啉

In the deep eutectic solvent which composed of choline chloride and zinc chloride, a series of 2,4-disubstituted quinolines were synthesized via cyclization coupling of 2-aminoacetophenone and aromatic alkyne. When the molar ratio of choline chloride and zinc chloride was 1:2, the yield up to 98% was achieved at 80℃ for 3 h. The method does not need additional catalyst, and has the advantages of mild reaction conditions, simple operation and a wide range of substrates.

Key words: deep eutectic solvent, choline chloride, zinc chloride, cyclization coupling, 2,4-disubstituted quinoline