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2021 , Vol. 41 >Issue 1: 229 - 240

DOI: https://doi.org/10.6023/cjoc202006003

综述与进展

亚铁离子荧光探针的研究进展

  • 马素芳 ,
  • 余强 ,
  • 陆利 ,
  • 李丽红 ,
  • 刘文 ,
  • 武志芳 ,
  • 李思进
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  • a 山西医科大学基础医学院 太原 030001
    b 山西医科大学医学影像学院 太原 030001
    c 山西医科大学第一医院核医学科 太原 030001
* Corresponding authors. E-mail: ;

收稿日期: 2020-06-02

  修回日期: 2020-07-10

  网络出版日期: 2020-08-01

基金资助

山西省青年科技研究基金(201901D211348); 山西省高等学校科技创新(2019L0409); 山西省高等学校科技创新(2019L0444); 山西医科大学博士启动基金(BS03201609)

收起

Recent Progress in Fluorescent Probes for the Detection of Ferrous Ion

  • Sufang Ma ,
  • Qiang Yu ,
  • Li Lu ,
  • Lihong Li ,
  • Wen Liu ,
  • Zhifang Wu ,
  • Sijin Li
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  • a School of Basic Medical Science, Shanxi Medical University, Taiyuan 030001
    b Medical Imaging Department, Shanxi Medical University, Taiyuan 030001
    c Department of Nuclear Medicine, First Hospital of Shanxi Medical University, Taiyuan 030001

Received date: 2020-06-02

  Revised date: 2020-07-10

  Online published: 2020-08-01

Supported by

the Youth Science Foundation of Shanxi Province(201901D211348); the Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi Province(2019L0409); the Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi Province(2019L0444); the Ph. D Startup Fund of Shanxi Medical University(BS03201609)

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摘要

铁作为生命系统中最丰富的过渡金属元素, 在许多生理和病理过程中发挥着无可替代的作用. 铁平衡失调不仅会导致诸如癌症、心血管疾病、神经退行性疾病等的发生和发展, 而且还会造成细胞铁死亡. 尽管细胞中的铁有Fe 2+和Fe 3+两种形式, 但细胞还原性微环境使其主要以Fe 2+形式存在. 因此, 开发一种对Fe 2+的特异性检测技术有助于深入了解Fe 2+与人类健康和疾病的关系. 随着荧光成像技术的发展, 近年来特异性检测Fe 2+的荧光探针引起学者们的极大关注. 对近10年来报道的Fe 2+荧光探针, 根据探针的设计思路、与Fe 2+的作用机理、光学特性以及其生物应用等方面进行了总结, 并对Fe 2+荧光探针的发展前景进行了展望.

关键词： 亚铁离子; 荧光探针; 荧光成像

本文引用格式

马素芳 , 余强 , 陆利 , 李丽红 , 刘文 , 武志芳 , 李思进 . 亚铁离子荧光探针的研究进展[J]. 有机化学, 2021 , 41(1) : 229 -240 . DOI: 10.6023/cjoc202006003

Abstract

Irons, as the most abundant transition metal in living system, play an irreplaceable role in many physiological and pathological processes. The misregulation of Fe 2+ homeostasis not only affects the occurence and delelopment of various diseases, such as cancer, cardiovascular disease and neurodegenerative disorders, but also induces ferroptosis. Although two forms of iron (Fe 2+ and Fe 3+) exist in cells, reducing microenvironment of cells makes it exist mainly in the form of Fe 2+. Therefore, developing a sensitive approach for Fe 2+ is particularly important because it may contribute to the in-depth understanding of the relationship between Fe 2+ and human health and disease. In recent years, with the rapid development of fluorescent imaging technique, fluorescent probes for the sensitive detection of Fe 2+ have attracted great interest. Fe 2+ fluorescent probes reported in the last ten years are summarized, according to probes design, sensing mechanisms with Fe 2+, optical properties and biological application. In addition, the development prospect of Fe 2+ fluorescent probes is predicted.

Key words： s ferrous ion; fluorescent probe; fluorescent imaging

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