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2021 , Vol. 41 >Issue 7: 2905 - 2909

DOI: https://doi.org/10.6023/cjoc202102052

研究简报

红树来源真菌Eupenicillium sp. HJ002发酵产物中三个新的聚酮类化合物

  • 蔡瑾 ,
  • 农旭华 ,
  • 王斌 ,
  • 曾尾女 ,
  • 黄国雷 ,
  • 张子怡 ,
  • 郑彩娟
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  • a 海南师范大学化学与化工学院 热带药用资源化学教育部重点实验室 海口 571158
    b 海南师范大学 海南省热带药用植物化学重点实验室 海口 571158

收稿日期: 2021-02-28

  修回日期: 2021-03-29

  网络出版日期: 2021-04-25

基金资助

海南省重点研发计划(ZDYF2019183); 国家自然科学基金(31760093); 海南省自然科学基金(220RC593); 海南省自然科学基金(218MS045)

收起

Three New Polyketides from the Culture of Mangrove-Derived FungusEupenicilliumsp. HJ002

  • Jin Cai ,
  • Xuhua Nong ,
  • Bin Wang ,
  • Weinü Zeng ,
  • Guolei Huang ,
  • Ziyi Zhang ,
  • Caijuan Zheng
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  • a Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158
    b Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Hainan Normal University, Haikou 571158
* Corresponding author. E-mail:

Received date: 2021-02-28

  Revised date: 2021-03-29

  Online published: 2021-04-25

Supported by

Key Research and Development Program of Hainan Province(ZDYF2019183); National Natural Science Foundation of China(31760093); National Natural Science Foundation of Hainan Province(220RC593); National Natural Science Foundation of Hainan Province(218MS045)

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摘要

从红树来源真菌Eupinillium sp. HJ002的发酵产物中分离获得一对新的差向异构体Eupenicilchromans A, B, 一个新的异香豆素衍生物eupenicillin A以及五个已知化合物. 通过多种波谱技术及电子圆二色谱(ECD)量子化学计算方法确定了新化合物的结构和绝对构型. Eupenicilchromans A, B显示强的抗氧化活性, IC50值分别为0.6和2.6 mmol/L, Eupenicilchroman A的活性强于阳性对照药trolox (IC50=1.6 mmol/L).

关键词： Eupenicillium sp; 异色原酮; 异香豆素; 抗氧化活性

本文引用格式

蔡瑾 , 农旭华 , 王斌 , 曾尾女 , 黄国雷 , 张子怡 , 郑彩娟 . 红树来源真菌Eupenicillium sp. HJ002发酵产物中三个新的聚酮类化合物[J]. 有机化学, 2021 , 41(7) : 2905 -2909 . DOI: 10.6023/cjoc202102052

Abstract

A pair of novel isochroman epimers eupenicilchromans A, B, and one new isocoumarin derivative eupenicilmarin A, together with five known compounds were isolated from the culture of mangrove-derived fungusEupenicilium sp. HJ002. The structures of the new compounds, including the absolute configurations, were determined by comprehensive spectroscopic methods, experimental and calculated electronic circular dichroism (ECD) methods. Eupenicilchromans A, B showed potent antioxidant activeties with the IC50 values of 0.6 and 2.6 mmol/L, respectively, and eupenicilchroman A displayed better antioxidant activity than the positive control trolox (IC50=1.6 mmol/L).

Key words： Eupenicillium sp.; isochroman; isocoumarin; antioxidant activity

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