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2021 , Vol. 41 >Issue 9: 3585 - 3592

DOI: https://doi.org/10.6023/cjoc202105010

研究论文

Selectfluor氧化合成2-芳基苯并噻唑的新方法

  • 傅琴姣 ,
  • 张瑞芹 ,
  • 裘浣沂 ,
  • 马仁超 ,
  • 马永敏
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  • 台州学院医药化工学院 浙江台州 318000

收稿日期: 2021-05-07

  修回日期: 2021-06-07

  网络出版日期: 2021-07-13

基金资助

浙江省领军型创新团队(2019R01005)

收起

A New Method for the Synthesis of 2-Arylbenzothiazoles Oxidized by Selectfluor

  • Qinjiao Fu ,
  • Ruiqin Zhang ,
  • Huanyi Qiu ,
  • Renchao Ma ,
  • Yongmin Ma
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  • School of Pharmaceutical and Chemical Engineering, Taizhou University, Taizhou, Zhejiang 318000
* Corresponding authors. E-mail: ;

Received date: 2021-05-07

  Revised date: 2021-06-07

  Online published: 2021-07-13

Supported by

Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang(2019R01005)

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摘要

开发了一种以芳基甲基酮或脂肪酮和2-氨基苯硫酚为原料, 正丁醇为溶剂, 120 ℃条件下经Selectfluor氧化合成2-取代苯并噻唑类衍生物的方法. 通过改变底物芳基甲基酮上的取代基可以获得具有生物活性的药物中间体.

关键词： 选择性氟试剂; 2-芳基苯并噻唑; 芳基甲基酮; 2-氨基苯硫酚; 氧化

本文引用格式

傅琴姣 , 张瑞芹 , 裘浣沂 , 马仁超 , 马永敏 . Selectfluor氧化合成2-芳基苯并噻唑的新方法[J]. 有机化学, 2021 , 41(9) : 3585 -3592 . DOI: 10.6023/cjoc202105010

Abstract

2-Arylbenzothiazoles were effectively synthesized via an oxidative process by Selectfluor in 1-butanol at 120 ℃, using 2-arylbenzothiazoles and aryl/aliphatic ketones as starting materials. Bioactive pharmaceutical intermediates were obtained by selecting substituents on the ring of aryl methyl ketones.

Key words： Selectfluor; 2-arylbenzothiazole; aryl methyl ketone; 2-aminobenzenethiol; oxidation

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