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2021 , Vol. 41 >Issue 11: 4154 - 4166

DOI: https://doi.org/10.6023/cjoc202107023

综述与进展

1,3,5-三嗪烷合成含氮杂环的反应研究进展

  • 张建涛 ,
  • 周鹏 ,
  • 肖朵朵 ,
  • 刘卫兵
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  • 广东石油化工学院化学学院 广东茂名 525000

收稿日期: 2021-07-09

  修回日期: 2021-08-11

  网络出版日期: 2021-08-25

基金资助

广东石油化工学院人才引进计划(2019rc048); 广东石油化工学院人才引进计划(2017rc07); 广东石油化工学院创新研究团队(519124); 广东省普通高校青年创新基金(2018KQNCX167)

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Research Progress of 1,3,5-Triazinanes in the Synthesis of Nitrogen-Containing Heterocycles

  • Jiantao Zhang ,
  • Peng Zhou ,
  • Duoduo Xiao ,
  • Weibing Liu
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  • College of Chemistry, Guangdong University of Petrochemical Technology, Maoming, Guangdong 525000
* Corresponding authors. E-mail: ;

Received date: 2021-07-09

  Revised date: 2021-08-11

  Online published: 2021-08-25

Supported by

Projects of Talents Recruitment of Guangdong University of Petrochemical Technology(2019rc048); Projects of Talents Recruitment of Guangdong University of Petrochemical Technology(2017rc07); Program for Innovative Research Team of Guangdong University of Petrochemical Technology(519124); Ordinary University Young Innovative Talents Project of Guangdong Province, China(2018KQNCX167)

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摘要

1,3,5-三嗪烷是一类重要的合成子, 可看成是甲醛亚胺的等价物, 参与各类含氮杂环骨架的构建. 近年来, 1,3,5-三嗪烷在含氮杂环化合物的构建中引起了越来越多的关注. 基于此, 系统综述了1,3,5-三嗪烷作为双原子、三原子以及四原子合成子参与[2+n], [3+n], [4+n]环加成反应构建含氮杂环化合物的反应研究进展, 总结了其在环加成、杂环化学以及药物化学中的应用, 并展望了基于1,3,5-三嗪烷参与构建含氮杂环骨架及其应用的未来发展趋势.

关键词： 1,3,5-三嗪烷; 含氮杂环; 合成子; 环加成反应; 药物化学

本文引用格式

张建涛 , 周鹏 , 肖朵朵 , 刘卫兵 . 1,3,5-三嗪烷合成含氮杂环的反应研究进展[J]. 有机化学, 2021 , 41(11) : 4154 -4166 . DOI: 10.6023/cjoc202107023

Abstract

1,3,5-Triazinanes are an important class of synthons, which could be regarded as the equivalent of formaldehyde imines in constructing various nitrogen-containing heterocyclic skeletons. In recent years, 1,3,5-triazinanes have attracted much attention in the construction of nitrogen-containing heterocyclic compounds. Based on this, the participation of 1,3,5-triazinanes as diatomic, triatomic and four-atom synthons in [2+n], [3+n], [4+n] cycloaddition reactions to construct nitrogen-containing heterocyclic compounds is systematically summarized. Its applications in cycloaddition, heterocyclic chemistry and pharmaceutical chemistry are also summarized. Moreover, the development of 1,3,5-triazinanes in the construction of nitrogen-containing heterocyclic skeletons and their future applications are also prospected.

Key words： 1,3,5-triazinane; nitrogen-containing heterocycle; synthon; cycloaddition reaction; pharmaceutical chemistry

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