有机化学 ›› 2021, Vol. 41 ›› Issue (11): 4154-4166.DOI: 10.6023/cjoc202107023 上一篇    下一篇

综述与进展

1,3,5-三嗪烷合成含氮杂环的反应研究进展

张建涛*(), 周鹏, 肖朵朵, 刘卫兵*()   

  1. 广东石油化工学院化学学院 广东茂名 525000
  • 收稿日期:2021-07-09 修回日期:2021-08-11 发布日期:2021-08-24
  • 通讯作者: 张建涛, 刘卫兵
  • 基金资助:
    广东石油化工学院人才引进计划(2019rc048); 广东石油化工学院人才引进计划(2017rc07); 广东石油化工学院创新研究团队(519124); 广东省普通高校青年创新基金(2018KQNCX167)

Research Progress of 1,3,5-Triazinanes in the Synthesis of Nitrogen-Containing Heterocycles

Jiantao Zhang(), Peng Zhou, Duoduo Xiao, Weibing Liu()   

  1. College of Chemistry, Guangdong University of Petrochemical Technology, Maoming, Guangdong 525000
  • Received:2021-07-09 Revised:2021-08-11 Published:2021-08-24
  • Contact: Jiantao Zhang, Weibing Liu
  • Supported by:
    Projects of Talents Recruitment of Guangdong University of Petrochemical Technology(2019rc048); Projects of Talents Recruitment of Guangdong University of Petrochemical Technology(2017rc07); Program for Innovative Research Team of Guangdong University of Petrochemical Technology(519124); Ordinary University Young Innovative Talents Project of Guangdong Province, China(2018KQNCX167)

1,3,5-三嗪烷是一类重要的合成子, 可看成是甲醛亚胺的等价物, 参与各类含氮杂环骨架的构建. 近年来, 1,3,5-三嗪烷在含氮杂环化合物的构建中引起了越来越多的关注. 基于此, 系统综述了1,3,5-三嗪烷作为双原子、三原子以及四原子合成子参与[2+n], [3+n], [4+n]环加成反应构建含氮杂环化合物的反应研究进展, 总结了其在环加成、杂环化学以及药物化学中的应用, 并展望了基于1,3,5-三嗪烷参与构建含氮杂环骨架及其应用的未来发展趋势.

关键词: 1,3,5-三嗪烷, 含氮杂环, 合成子, 环加成反应, 药物化学

1,3,5-Triazinanes are an important class of synthons, which could be regarded as the equivalent of formaldehyde imines in constructing various nitrogen-containing heterocyclic skeletons. In recent years, 1,3,5-triazinanes have attracted much attention in the construction of nitrogen-containing heterocyclic compounds. Based on this, the participation of 1,3,5-triazinanes as diatomic, triatomic and four-atom synthons in [2+n], [3+n], [4+n] cycloaddition reactions to construct nitrogen-containing heterocyclic compounds is systematically summarized. Its applications in cycloaddition, heterocyclic chemistry and pharmaceutical chemistry are also summarized. Moreover, the development of 1,3,5-triazinanes in the construction of nitrogen-containing heterocyclic skeletons and their future applications are also prospected.

Key words: 1,3,5-triazinane, nitrogen-containing heterocycle, synthon, cycloaddition reaction, pharmaceutical chemistry