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2021 , Vol. 41 >Issue 12: 4758 - 4765

DOI: https://doi.org/10.6023/cjoc202109011

研究论文

三甲基溴硅烷诱导的N-保护吲哚的区域选择性二聚合成2,3′-吲哚基二氢吲哚

  • 唐爱玲 ,
  • 金伟伟 ,
  • 刘晨江
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  • 新疆大学化学学院 乌鲁木齐 830046

收稿日期: 2021-09-06

  修回日期: 2021-10-19

  网络出版日期: 2021-11-03

基金资助

国家自然科学基金(21572195); 国家自然科学基金(21702175); 国家自然科学基金(21961037)

收起

Trimethylsilyl Bromide-Induced Regioselective Dimerization of N-Protected Indoles to 2,3'-Linked Indolylindolines

  • Ailing Tang ,
  • Weiwei Jin ,
  • Chenjiang Liu
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  • College of Chemistry, Xinjiang University, Urumqi 830046
* Corresponding authors. E-mail: ;

Received date: 2021-09-06

  Revised date: 2021-10-19

  Online published: 2021-11-03

Supported by

National Natural Science Foundation of China(21572195); National Natural Science Foundation of China(21702175); National Natural Science Foundation of China(21961037)

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摘要

报道了一种三甲基溴硅烷促进的通过碳-碳键交叉偶联反应合成N-甲基吲哚二聚体的方法. 在温和条件下以最高95%的收率方便地合成了一系列2,3′-吲哚基二氢吲哚类化合物. 克级反应证明了该方法的实用性. 初步研究了目标产物的紫外-可见吸收和荧光光谱性质.

关键词： 吲哚; 二聚; 交叉偶联; 吲哚基二氢吲哚

本文引用格式

唐爱玲 , 金伟伟 , 刘晨江 . 三甲基溴硅烷诱导的N-保护吲哚的区域选择性二聚合成2,3′-吲哚基二氢吲哚[J]. 有机化学, 2021 , 41(12) : 4758 -4765 . DOI: 10.6023/cjoc202109011

Abstract

A dimerization of N-methylindoles by trimethylsilyl bromide promoted C—C bond cross coupling reactions is described. A series of 2,3'-linked indolylindolines are smoothly installed under mild reaction conditions with up to 95% yields. The gram scale reactions demonstrate the practicality of this protocol. The UV-vis absorption and fluorescence spectra properties of target products are preliminarily studied.

Key words： indole; dimerization; cross-coupling; indolylindoline

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