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2023 , Vol. 43 >Issue 1: 1 - 16

DOI: https://doi.org/10.6023/cjoc202205033

综述与进展

过渡金属催化的酮羰基导向C—H键官能化反应进展

  • 陈泗林 ,
  • 杨芸辉 ,
  • 陈超 ,
  • 王从洋
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  • a 五邑大学生物科技与大健康学院 广东江门 529020
    b 中国科学院化学研究所 中国科学院分子识别与功能重点实验室 北京 100190
    c 中国科学院大学 北京 100049

收稿日期: 2022-05-20

  修回日期: 2022-08-09

  网络出版日期: 2022-08-25

基金资助

国家自然科学基金(22025109); 国家自然科学基金(21772202); 北京分子科学国家实验室(BNLMS-CXXM-201901); 王宽诚教育基金会资助项目

收起

Advances in Transition-Metal-Catalyzed Keto Carbonyl-Directed C—H Bond Functionalization Reactions

  • Silin Chen ,
  • Yunhui Yang ,
  • Chao Chen ,
  • Congyang Wang
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  • a School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, Guangdong 529020
    b CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190
    c University of Chinese Academy of Sciences, Beijing 100049
* Corresponding authors. E-mail: ;
;

Received date: 2022-05-20

  Revised date: 2022-08-09

  Online published: 2022-08-25

Supported by

National Natural Science Foundation of China(22025109); National Natural Science Foundation of China(21772202); Beijing National Laboratory for Molecular Sciences(BNLMS-CXXM-201901); K. C. Wong Education Foundation

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摘要

近二十年来, 过渡金属催化的酮羰基导向C—H键活化已发展成为在酮的非传统反应位点构建碳碳键和碳杂键(杂原子为氮、氟和氧原子等)的强有力而快捷的手段. 其中, 钌、铑、钯、铱等贵金属催化的酮羰基导向C—H键活化反应得到了广泛研究, 而廉价3d金属锰、铁和钴催化的酮羰基导向C—H活化反应逐渐成为当前研究的热点. 文中按照过渡金属催化的酮羰基导向C—H键官能化的不同反应类型(烷基化、烯基化、酰胺化、芳基化、环化等)综述了该领域近年来(2014~2021)的研究进展.

关键词： 过渡金属; 催化; 酮羰基; C—H键官能化; 有机合成

本文引用格式

陈泗林 , 杨芸辉 , 陈超 , 王从洋 . 过渡金属催化的酮羰基导向C—H键官能化反应进展[J]. 有机化学, 2023 , 43(1) : 1 -16 . DOI: 10.6023/cjoc202205033

Abstract

In the past two decades, transition-metal-catalyzed keto carbonyl-directed C—H bond activation has evloved as a powerful and convenient tool for the construction of C—C and C—X (X=N, F, O) bonds at the unconventional reaction sites of ketones. Among them, keto carbonyl-directed C—H bond activation reactions catalyzed by noble metals, involving ruthenium, rhodium, palladium and iridium, have been widely explored, whilst inexpensive 3d metals, such as manganese, iron and cobalt, have gradually emerged as hotspot catalysts in keto carbonyl-directed C—H activation reactions recently. In this review, advances on transition-metal-catalyzed keto carbonyl-directed C—H bond functionalization reactions from 2014 to 2021 are summarized, which are devided by reaction categories such as alkylation, alkenylation, amidation, arylation, cyclization, and so on.

Key words： transition metals; catalysis; keto carbonyl; C—H bond functionalization; organic synthesis

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