Rh催化N-磺酰腙的偕-二氟烯丙基化反应
收稿日期: 2022-05-31
修回日期: 2022-07-14
网络出版日期: 2022-08-25
基金资助
国家自然科学基金(22161024); 云南省科技计划(2019FD048)
Rh-Catalyzed gem-Difluoroallylation of N-Tosylhydrazones
Received date: 2022-05-31
Revised date: 2022-07-14
Online published: 2022-08-25
Supported by
National Natural Science Foundation of China(22161024); Science and Technology Planning Project of Yunnan Province(2019FD048)
发展了一种铑催化N-磺酰腙和3,3-二氟烯丙基硫化物的重排反应合成偕-二氟烯丙基化合物的高效方法. 该方法具有中等至优异的收率和良好的官能团耐受性, 并通过两步一锅、克级合成和产物的衍生化验证了其实用性.
关键词： N-磺酰腙; 3,3-二氟烯丙基硫化物; 铑催化; 偕-二氟烯丙基化
王家状 , 滕丽果 , 熊绍棋 , 肖铁波 , 江玉波 . Rh催化N-磺酰腙的偕-二氟烯丙基化反应[J]. 有机化学, 2022 , 42(11) : 3658 -3667 . DOI: 10.6023/cjoc202205054
A rhodium-catalyzed rearrangement reaction of N-tosylhydrazones and 3,3-difluoroallyl sulfides was developed. This protocal provided a facile and efficient synthesis route to gem-difluoroallyl compounds with medium to excellent yield and good functional group tolerance. Moreover, the applicability of current method has been demonstrated by one-pot reaction, gram-scale synthesis and further transformations.
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