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2023 , Vol. 43 >Issue 1: 57 - 73

DOI: https://doi.org/10.6023/cjoc202207006

综述与进展

构建2H-吡咯-2-酮骨架的研究进展

  • 刘东汉 ,
  • 鲁席杭 ,
  • 柴张梦洁 ,
  • 杨浩琦 ,
  • 孙瑜琳 ,
  • 余富朝
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  • 昆明理工大学生命科学与技术学院 昆明 650504

收稿日期: 2022-07-04

  修回日期: 2022-08-02

  网络出版日期: 2022-09-15

基金资助

国家自然科学基金(21961018); 云南省自然科学基金(201901T070302)

收起

Progress in Construction of 2H-Pyrrol-2-ones Skeleton

  • Donghan Liu ,
  • Xihang Lu ,
  • Zhangmengjie Chai ,
  • Haoqi Yang ,
  • Yulin Sun ,
  • Fuchao Yu
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  • Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650504
* Corresponding author. E-mail: ,

Received date: 2022-07-04

  Revised date: 2022-08-02

  Online published: 2022-09-15

Supported by

National Natural Science Foundation of China(21961018); Yunnan Provincial Natural Science Foundation(201901T070302)

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摘要

2H-吡咯-2-酮作为一类重要的γ-内酰胺类化合物, 因其广泛存在于天然产物、药物和生物活性分子之中, 同时也是药物研发和有机合成中的主要合成中间体, 故备受有机合成工作者的关注. 近年来, 基于2H-吡咯-2-酮骨架包括1,5-二氢-2H-吡咯-2-酮的合成方法和策略取得了长足发展. 通过总结不同合成方法和策略, 分别对三类2H-吡咯-2-酮骨架的合成方法学的研究进展予以综述.

关键词： 2H-吡咯-2-酮; γ-内酰胺; 过渡金属催化; 串联环化反应

本文引用格式

刘东汉 , 鲁席杭 , 柴张梦洁 , 杨浩琦 , 孙瑜琳 , 余富朝 . 构建2H-吡咯-2-酮骨架的研究进展[J]. 有机化学, 2023 , 43(1) : 57 -73 . DOI: 10.6023/cjoc202207006

Abstract

2H-Pyrrol-2-ones as an important class of γ-lactam compounds, widely exist in the structure of natural products, drugs and biologically active molecules, and they are also the important synthetic intermediates in drug development and organic synthesis. In recent years, the synthesis methods and strategies based on 2H-pyrrol-2-ones skeleton including 1,5-dihydro-2H-pyrrol-2-ones have made great progress. In this paper, the different synthetic methods and strategies for the construction of 2H-pyrrol-2-one skeletons are summarized.

Key words： 2H-pyrrol-2-one; γ-lactam; transition metal catalysis; cascade cyclization reaction

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