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2023 , Vol. 43 >Issue 4: 1310 - 1324

DOI: https://doi.org/10.6023/cjoc202211012

综述与进展

吲哚-3-硫醚类化合物的合成研究进展

  • 童宇星 ,
  • 王子维 ,
  • 刘奔 ,
  • 徐耀威 ,
  • 高颂 ,
  • 唐向兵 ,
  • 张兴华
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  • a 湖北中烟工业有限责任公司 武汉 430040
    b 湖北新业烟草薄片开发有限公司 武汉 430056
    c 重组烟叶应用技术研究湖北省重点实验室 武汉 430056
    d 上海应用技术大学化学与环境工程学院 上海 201418

收稿日期: 2022-11-10

  修回日期: 2022-11-30

  网络出版日期: 2022-12-12

基金资助

国家自然科学基金(21871182)

收起

Recent Advances in Synthesis of 3-Sulfenylated Indoles

  • Yuxing Tong ,
  • Ziwei Wang ,
  • Ben Liu ,
  • Yaowei Xu ,
  • Song Gao ,
  • Xiangbing Tang ,
  • Xinghua Zhang
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  • a China Tobacco Hubei Industrial Co., Ltd., Wuhan 430040
    b Hubei Xinye Reconstituted Tobacco Development Co., Ltd, Wuhan 430056
    c Applied Technology Research of Reconstituted Tobacco Hubei Province Key Laboratory, Wuhan 43005
    d School of Chemical and Environmental Engineering, Shanghai Institute of Technology, Shanghai 201418
* Corresponding author. ;

Received date: 2022-11-10

  Revised date: 2022-11-30

  Online published: 2022-12-12

Supported by

National Natural Science Foundation of China(21871182)

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摘要

吲哚-3-硫醚类化合物是一类重要的的生物活性分子, 在医药以及农用化学品等领域具有广泛应用. 如何通过简单、高效的方法构建此类结构单元, 尤其是实现吲哚C-3原子上C—S键的选择性合成, 已成为近年来高生物活性分子设计开发的重要手段. 总结了通过吲哚3位C—H键直接选择性硫醚化制备吲哚-3-硫醚类化合物的方法, 根据硫元素的不同来源对此类反应的研究进展进行综述.

关键词： 硫醚化; C—S键; 交叉偶联

本文引用格式

童宇星 , 王子维 , 刘奔 , 徐耀威 , 高颂 , 唐向兵 , 张兴华 . 吲哚-3-硫醚类化合物的合成研究进展[J]. 有机化学, 2023 , 43(4) : 1310 -1324 . DOI: 10.6023/cjoc202211012

Abstract

3‑Sulfenylated indoles have been widely used in pharmaceutical and agrochemical industry due to their inherent potential biological activity. How to synthesize bioactive molecules containing such structural units via simple and efficient method, especially to achieve the selective construction of C—S bond on indole C-3 atom, has become an important means for the design and development of highly bioactive molecules in recent years. The recent development in the regioselective synthesis of 3-sulfenylated indoles via the direct sulfenylation of indoles at the C-3 position on the basis of different types of sulfenylating reagents is summarized.

Key words： sulfenylation; C—S bond; cross-coupling

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